ATI RN
Pediatric Immunization Practice Questions Questions
Question 1 of 5
The route of antigen processing (cytosolic versus vesicle bound) determines whether an antigen is presented by MHC class II molecules to a TCR on a CD4+ helper (TH) cell, or by major histocompatibility complex (MHC) class I molecules to a TCR on a CD8+ cytotoxic T cell.
Correct Answer: A
Rationale: Cytosolic antigens go to MHC I (CD8+), vesicle-bound to MHC II (CD4+). This is true.
Question 2 of 5
Opsonization is the process by which bacteria and other cells are made available for phagocytosis and involves opsonin or IgG. Which complement components is/are mainly involved?
Correct Answer: B
Rationale: C3b is the primary opsonin in the complement system.
Question 3 of 5
Makes integrins more 'sticky'
Correct Answer: D
Rationale: Chemokines activate integrins to enhance adhesion.
Question 4 of 5
Parasitic worm eggs are resistant to low pH and proteolytic digestion in the stomach. Adult worms living inside the lower gut are protected from many of the components of the immune response. Mast cells respond to worms. What immunoglobulin activates these mast cells, leading to degranulation?
Correct Answer: C
Rationale: IgE is the key immunoglobulin involved in allergic and parasitic responses, binding to mast cells and triggering degranulation to combat worms.
Question 5 of 5
Natural killer cells are thought to fill the gap between initial innate response and adaptive immune response. They evolved to detect low levels of MHC caused by the diseases of and
Correct Answer: C
Rationale: NK cells detect reduced MHC class I expression, common in herpes virus infections and tumor cells, bridging innate and adaptive immunity.