The reason of diuretics administration for hypertension treatment is:

Correct Answer: B

Rationale: The correct answer is B because diuretics help reduce blood volume and sodium ions, leading to decreased blood pressure. By promoting diuresis, diuretics decrease the workload on the heart and blood vessels, thus helping to manage hypertension. A: Blocking adrenergic transmission is typically done by beta-blockers, not diuretics. C: Depression of the renin-angiotensin-aldosterone system is targeted by ACE inhibitors or angiotensin receptor blockers, not diuretics. D: Depression of the vasomotor center is related to centrally acting antihypertensive medications, not diuretics.

Correct Answer: D

Rationale: Step-by-step rationale: 1. Synthetic estrogens are used to treat conditions related to hormonal imbalances. 2. Primary hypogonadism, postmenopausal hormonal therapy, and hormonal contraception are common indications for synthetic estrogens. 3. Simple obesity is not a condition related to hormonal imbalances. 4. Thus, using synthetic estrogens for the treatment of simple obesity is not a valid indication. Summary: A, B, and C are valid indications for synthetic estrogens as they involve hormonal imbalances. D is incorrect as simple obesity does not involve hormonal imbalances.

Correct Answer: A

Rationale: The correct answer is A: TRUE. Ketoprofen is indeed a propionic acid derivative that inhibits both cyclooxygenase and lipoxygenase nonselectively. This is because ketoprofen belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs), which work by inhibiting cyclooxygenase enzymes to reduce inflammation and pain. Additionally, ketoprofen has been shown to inhibit lipoxygenase, another enzyme involved in the inflammatory process. Therefore, this statement accurately describes the pharmacological actions of ketoprofen. Choices B and C are incorrect because the statement is true, and choice D is incorrect as it suggests all options are correct when only option A is accurate in this case.

Correct Answer: D

Rationale: Interferon gamma is associated with the side effect of fatigue due to its immunomodulatory effects causing systemic symptoms. This side effect is commonly reported in patients receiving interferon therapy. Hypertension, pulmonary edema, and nephrotoxicity are not typically linked to interferon gamma therapy. Thus, the correct answer is D.

Correct Answer: D

Rationale: The correct answer is D - All of the above. Cholestyramine binds bile acids, leading to malabsorption of fat-soluble vitamins like vitamin K. Coumarins inhibit the recycling of vitamin K epoxide, reducing its availability. Certain antibiotics disrupt gut flora, affecting vitamin K production. Therefore, all choices prevent vitamin K from exerting its metabolic effects.