The reason of beta-blockers administration for hypertension treatment is:

Correct Answer: C

Rationale: The correct answer is C: Decreasing of heart work. Beta-blockers reduce blood pressure by decreasing the heart's workload through blocking the effects of adrenaline on the heart, resulting in lowered heart rate and force of contraction. This reduces the amount of blood pumped by the heart, leading to decreased blood pressure. The other choices are incorrect because: A: Peripheral vasodilatation - Beta-blockers actually cause vasoconstriction, not vasodilatation. B: Diminishing of blood volume - Beta-blockers do not directly affect blood volume. D: Depression of vasomotor center - Beta-blockers primarily act on the heart, not the vasomotor center.

Correct Answer: D

Rationale: The correct answer is D, "All of the above." Insulin therapy can lead to hypoglycemia due to excessive insulin dosage, insulin allergy in some rare cases, and lipodystrophy at injection sites from repeated injections. Each complication is a potential risk of insulin therapy, making all choices relevant. Therefore, option D is the correct answer as it encompasses all possible complications. Choices A, B, and C individually address specific complications but do not cover the full scope of potential issues associated with insulin therapy, making them incorrect in this context.

Correct Answer: C

Rationale: Rationale: C: Aspirin inhibits phospholipase A2. This statement is FALSE. Aspirin does not directly inhibit phospholipase A2. The correct answer is C. Summary: A: TRUE - Aspirin irreversibly inhibits COX. B: TRUE - Aspirin interferes with the chemical mediators of the kallikrein system. D: TRUE - Aspirin inhibits thromboxane A2 formation.

Correct Answer: C

Rationale: The correct answer is C: Inhibits calcineurin. Sirolimus inhibits the mTOR pathway by binding to FKBP12 and forming a complex that inhibits the activity of mTOR complex 1. Calcineurin is not directly involved in the mechanism of action of sirolimus. Choice A is incorrect because sirolimus does not involve anti-idiotype antibodies. Choice B is incorrect because sirolimus does not modulate the CD3 receptor. Choice D is incorrect because sirolimus does not mediate ADCC towards T lymphocytes.

Correct Answer: B

Rationale: Step 1: Identify the statement - "Vitamin K enhances the anticoagulant property of coumarins." Step 2: Recall that Vitamin K is actually involved in blood clotting, counteracting anticoagulants. Step 3: Understand that coumarins are anticoagulants that work by inhibiting Vitamin K. Step 4: Therefore, the statement is FALSE as Vitamin K doesn't enhance but counteracts coumarins. Summary: Choice A is incorrect because the statement is false, Choice C and D are incorrect as they do not apply to the given scenario.