ATI RN
ATI PN Pharmacology Proctored Exam 2023 Questions
Question 1 of 5
The physiologic differences in the pediatric patient compared with the adult patient affect the amount of drug needed to produce a therapeutic effect. The nurse is aware that one of the main differences is that infants have
Correct Answer: D
Rationale: Infants have a higher percentage of total body water (approximately 75%) compared to adults. This difference affects the distribution and concentration of water-soluble drugs, often requiring adjustments in dosing to achieve therapeutic effects. Increased protein in circulation, lower fat composition, and more muscular body composition are not primary factors influencing drug therapy in infants. Therefore, the nurse must consider the higher water composition when calculating drug dosages for pediatric patients.
Question 2 of 5
One hour after receiving intravenous morphine sulfate, a patient reports generalized itching. The nurse assesses the patient and notes clear breath sounds, no rash, respirations of 14 breaths per minute, a heart rate of 68 beats per minute, and a blood pressure of 110/70 mm Hg. Which action will the nurse take?
Correct Answer: D
Rationale: The nurse should prepare an epinephrine injection in case of an anaphylactic reaction. While generalized itching is a common side effect of morphine, the presence of itching along with clear breath sounds and absence of rash may suggest a possible allergic reaction. Anaphylactic reactions can be life-threatening and may present with symptoms such as itching, respiratory distress, and cardiovascular collapse. Therefore, having epinephrine readily available is crucial in case an anaphylactic reaction occurs, as it is the treatment of choice for such a reaction.
Question 3 of 5
A patient tells the nurse that he likes to eat large amounts of garlic to help lower his cholesterol levels naturally. The nurse reviews his medication history and notes that which drug has a potential interaction with the garlic?
Correct Answer: B
Rationale: Garlic has been reported to have potential interactions with warfarin, which is an anticoagulant medication. Garlic contains compounds that can also act as anticoagulants, and the combination with warfarin may increase the risk of bleeding. It can lead to potentiation of the anticoagulant effects of warfarin, increasing the risk of bleeding complications. Therefore, patients taking warfarin should be cautious about consuming large amounts of garlic or garlic supplements. This potential interaction highlights the importance of discussing all dietary supplements with healthcare providers to prevent adverse events.
Question 4 of 5
A patient has been changed from a first generation H1 receptor antagonist to a second generation H1 receptor antagonist. The nurse evaluates that the patient understands the benefit of this change when which statement is made?
Correct Answer: D
Rationale: Second-generation H1 antagonists (e.g., loratadine) are less lipophilic, reducing blood-brain barrier crossing, thus causing less sedation than first-generation ones (e.g., diphenhydramine). 'This drug will not make me as sleepy' shows the patient grasps this benefit, improving daily function. Alcohol still risks sedation. Dry mouth and urinary issues are anticholinergic effects less reduced in second-generation drugs. Choice D confirms understanding of the primary advantage.
Question 5 of 5
Following ingestion, a drug crosses a membrane from an area of higher concentration to an area of lower concentration. This is an example of
Correct Answer: C
Rationale: Diffusion moves drugs passively from high to low concentration across membranes, like oral absorption, a pharmacokinetic staple. Active transport uses energy against gradients. Osmosis is water-specific. Metabolism alters drugs chemically. Diffusion fits, driving initial uptake.