ATI RN
NCLEX questions on chemotherapy drugs Questions
Question 1 of 5
The penicillin G preparation with the longest duration of action is:
Correct Answer: A
Rationale: Benzathine penicillin G has the longest duration (weeks) due to its slow-release intramuscular formulation, ideal for syphilis.
Question 2 of 5
A patient on antibacterial therapy has to do an operation in which a skeletal muscle relaxant may be used. He will be at risk if this antimicrobial is:
Correct Answer: B
Rationale: Aminoglycosides (e.g., gentamicin) potentiate neuromuscular blockade, risking respiratory depression with muscle relaxants.
Question 3 of 5
A 10 year old boy with glucose-6-phosphate dehydrogenase deficiency has typhoid fever, the best drug for treatment is:
Correct Answer: C
Rationale: Amoxicillin is safe in G6PD deficiency for typhoid (Salmonella typhi). Co-trimoxazole and chloramphenicol risk hemolysis, and ciprofloxacin is avoided in children.
Question 4 of 5
A man with a history of multiple antibiotic resistance is given a prophylactic IV dose of antibiotic before surgery. As the antibiotic is being infused, the patient becomes flushed over most of his body. Which of the following antibiotics is most likely responsible?
Correct Answer: C
Rationale: Vancomycin causes ‘red man syndrome’ (flushing) due to histamine release if infused too rapidly.
Question 5 of 5
A patient develops severe, watery diarrhea, fever & abdominal pain. Clostridium difficile infection in the gut is confirmed. The antimicrobial therapy for this antibiotic-associated pseudomembranous colitis is:
Correct Answer: D
Rationale: Metronidazole or vancomycin treats C. difficile colitis; vancomycin is preferred for severe cases, and both are effective.