The pathophysiologic basis for antiparkinsonism therapy is:

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Question 1 of 5

The pathophysiologic basis for antiparkinsonism therapy is:

Correct Answer: A

Rationale: Antiparkinsonism therapy targets the selective loss of dopaminergic neurons in the substantia nigra, which disrupts the balance between dopamine and acetylcholine in the basal ganglia. Treatments aim to restore dopamine levels or reduce cholinergic overactivity, making 'A selective loss of dopaminergic neurons' the correct pathophysiological basis.

Question 2 of 5

Indicate selective catechol-O-methyltransferase inhibitor, which prolongs the action of levodopa by diminishing its peripheral metabolism:

Correct Answer: C

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Question 3 of 5

Which of the following preparations combines carbidopa and levodopa in a fixed proportion?

Correct Answer: B

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Question 4 of 5

Second-order pain is:

Correct Answer: B

Rationale: Second-order pain, often called slow pain, is dull, burning, and poorly localized, transmitted via unmyelinated C fibers. Sharp, well-localized pain (first-order) is linked to A-delta fibers, and second-order pain typically requires opioids, not just non-narcotics, making 'Dull, burning pain' correct.

Question 5 of 5

Which of the following opioid analgesics is a strong mu receptor agonist?

Correct Answer: B

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

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