ATI RN
Genetic Pediatric Questions
Question 1 of 5
The oncogene that causes Burkitt’s lymphoma results from:
Correct Answer: A
Rationale: Burkitt’s lymphoma involves a t(8;14) translocation, moving MYC (proto-oncogene) near an immunoglobulin gene, increasing expression.
Question 2 of 5
BRCA1 and BRCA2 mutations:
Correct Answer: B
Rationale: BRCA1/2 mutations are autosomal dominant with incomplete penetrance; not all carriers develop cancer.
Question 3 of 5
Which of the following are known to cause cancer?
Correct Answer: D
Rationale: All are carcinogenic: viruses (e.g., HPV), radiation (e.g., UV), and chemicals (e.g., asbestos).
Question 4 of 5
All of the following are correct except:
Correct Answer: D
Rationale: E is incorrect. Tumor suppressors are typically inactivated in cancer, not overexpressed.
Question 5 of 5
Which of the following is not a tumour suppressor gene?
Correct Answer: D
Rationale: RET is a proto-oncogene (gain-of-function in cancer); APC, NF1, RB1 are tumor suppressors.