ATI RN
ATI Pharmacology Practice A Questions
Question 1 of 5
The nurse teaching a pre-conception class would tell participants that they should be most careful about exposure to drugs during which stage of pregnancy?
Correct Answer: D
Rationale: The embryonic stage (weeks 3-8) is peak risk-organogenesis makes fetuses vulnerable to teratogens (e.g., alcohol causing FAS), per developmental biology. Equal risk ignores stages. Pre-implantation (pre-week 3) has less organ impact. Third trimester affects growth, less malformation. Embryonic caution is critical, shaping warnings.
Question 2 of 5
A 23-year-old man is a driver who is involved in a motor vehicle accident. He is found to have a blood alcohol level of 850 mg/dL. Because of the way the body handles ethanol, the conventional 'half-life' to describe its metabolism does not apply. Which of the following drugs at therapeutic concentrations exhibits the same property?
Correct Answer: B
Rationale: Ethanol's zero-order metabolism (constant rate) differs from first-order half-life kinetics. Phenytoin shares this-saturating hepatic enzymes at therapeutic levels, making it correct. Ibuprofen , Simvastatin , Tolbutamide , and Valproic acid (E) follow first-order kinetics. Phenytoin's saturation mimics ethanol's fixed clearance, relevant to toxicology.
Question 3 of 5
An 18-year-old college student is hanging shelves in his dorm room. He accidentally hits his thumb with the hammer, which subsequently becomes swollen and red. He takes some aspirin for the pain. Many enzymes and other proteins are activated in response to injury leading to inflammation. Production of which of the following mediators is inhibited by aspirin?
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 4 of 5
A 34-year-old man with seasonal allergic rhinitis that has been refractory to oral antihistamines is now placed on Singulair, a leukotriene receptor blocker, to see if this will improve symptoms. Important interactions with this medication include which of the following?
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 5 of 5
Which antipsychotic has the most sedative potential and is sometimes questionably used as a hypnotic agent in certain clinical settings?
Correct Answer: C
Rationale: Quetiapine, a second-generation antipsychotic, has strong histamine H1 antagonism, conferring potent sedation, especially at low doses. This property leads to off-label use as a hypnotic in insomnia, though controversial due to metabolic risks. Fluphenazine and haloperidol, high-potency first-generation drugs, lack sedation, focusing on D2 blockade. Thiothixene, mid-potency, has minimal sedative effects. Iloperidone is less sedating. Quetiapine's antihistaminic action, backed by clinical practice, makes it the most sedative antipsychotic, often leveraged for sleep despite primary indications.