The nurse is reviewing the client's history who is about to take Methotrexate. Which of the following drugs can be safely administered together with methotrexate?

Correct Answer: B

Rationale: Folic acid supplementation is recommended for patients on methotrexate to reduce the risk of side effects such as mucositis and myelosuppression. Tetracycline, sulfamethoxazole, and phenytoin can interact with methotrexate, increasing its toxicity. Folic acid helps mitigate these adverse effects without interfering with the drug's efficacy.

Correct Answer: A

Rationale: The pain threshold is defined as the least stimulus intensity at which a subject perceives pain. It represents the point at which a person first acknowledges experiencing pain. Pain threshold varies among individuals and can be influenced by various factors such as genetics, emotional state, culture, and past experiences with pain. It is an important concept in understanding an individual's sensitivity to pain and can be different from their pain tolerance level, which refers to the maximum level of pain a person is willing to endure. Analgesia involves the relief of pain, nociception is the body's physiological response to noxious stimuli, and polymodal refers to nerve fibers that respond to multiple types of stimuli.

Correct Answer: A

Rationale: The patient should call 911 immediately. Angina is characterized by chest pain or discomfort that occurs when the heart muscle does not receive enough oxygen-rich blood. The fact that the patient continued to experience chest pain even while sitting down is concerning and suggests that he may be having an acute coronary event, such as a heart attack. In this situation, prompt medical attention is crucial to assess and manage the situation appropriately. It is important not to delay seeking emergency help when experiencing chest pain, especially for a patient with a known history of angina.

Correct Answer: A

Rationale: Enteral route of drug administration involves placing the drug directly into the gastrointestinal tract (such as oral or rectal routes) for absorption into the systemic circulation. This route requires the drug to pass through the digestive system before being absorbed, allowing for slower and more sustained release of the medication compared to other routes. Examples of enteral drug administration include oral tablets, capsules, and liquids as well as rectal suppositories.

Correct Answer: B

Rationale: Colistimethate sodium is a polymyxin antibiotic used to treat multidrug-resistant Gram-negative infections, including Pseudomonas aeruginosa. It is not safe for patients with renal impairments and does not prevent antibiotic resistance. Its primary purpose is to treat infections caused by resistant Gram-negative bacteria.