ATI RN
Pharmacology Assessment 1 ATI Capstone Questions
Question 1 of 5
The nurse is caring for a 55-year-old patient receiving metoprolol (Lopressor). What statement by the patient would lead the nurse to believe that he needs additional instruction?
Correct Answer: B
Rationale: OTC medications can interact to increase or decrease the effects of antiadrenergic drugs. Antacids decrease the effects of beta-adrenergic blocking drugs. Decreased antihypertensive effects result when taken with ibuprofen. Other options reflect correct statements and would not indicate that the patient would need further instruction. The nurse should educate the patient about potential drug interactions and the importance of consulting their healthcare provider before taking OTC medications.
Question 2 of 5
Medications bound to protein have the following effect:
Correct Answer: C
Rationale: When medications are bound to proteins in the bloodstream, they are inactive and unable to exert their therapeutic effects. Only the unbound (free) fraction of the drug is pharmacologically active. Therefore, the more a drug is bound to protein, the less available it is for its desired effect. Protein binding also affects the drug's distribution and metabolism, but it does not enhance availability or increase liver metabolism. Rapid distribution to receptor sites is influenced by other factors, such as blood flow and tissue permeability.
Question 3 of 5
A student nurse was asked by the nurse instructor to explain the procedure for the administration of erythromycin ointment to the eyes of the newborn. Which of the following statements made by the student indicates a need for further research?
Correct Answer: D
Rationale: Flushing the newborn's eyes after instilling erythromycin ointment is incorrect because it would remove the medication, rendering it ineffective. The ointment is applied to the conjunctival sacs to prevent ophthalmia neonatorum, a bacterial infection that can occur during delivery. Cleaning the eyes before administration and applying the ointment within an hour after delivery are correct steps. Therefore, the statement about flushing the eyes indicates a need for further education.
Question 4 of 5
Which drug combination is recommended for chronic hepatitis C infection?
Correct Answer: C
Rationale: Chronic hepatitis C (HCV) treatment targets viral clearance. Pegylated interferon alfa boosts immunity, lamivudine treats HBV, not HCV, so that's incorrect. Adefovir also targets HBV, not HCV. Pegylated interferon alfa with ribavirin, an antiviral, is a historical standard for HCV, enhancing sustained virologic response across genotypes, the recommended combo. Adefovir/lamivudine suits HBV, oseltamivir/zanamivir influenza. Ribavirin's synergy with interferon was key before direct-acting antivirals, effective for this condition.
Question 5 of 5
With regard to non-depolarising neuromuscular blocking drugs:
Correct Answer: A
Rationale: Pancuronium is primarily renally eliminated, a true statement, prolonged in kidney failure. Rocuronium, a steroidal agent, not isoquinolone (like atracurium), is false. Rocuronium is hepatically metabolized, not via Hofmann elimination (atracurium does), so that's false. Vecuronium is mostly biliary excreted, not renal, making that false. Atracurium uses plasma esterases and Hofmann elimination, not pseudocholinesterases alone. Pancuronium's renal clearance is critical for surgical planning, especially in renal patients.