The nurse administers IV ceftriaxone (Rocephin) to a client with pneumonia. Which precaution should the nurse take?

Correct Answer: C

Rationale: Ceftriaxone, a cephalosporin, treats pneumonia but risks hypersensitivity (e.g., rash, anaphylaxis). Monitoring for allergic reactions ensures safety, a key precaution. Dilution is standard but not the focus'protocol varies. Rapid infusion is too fast'30 minutes is typical. Undiluted risks irritation. Allergy monitoring aligns with cephalosporin's profile, critical in pneumonia where rapid intervention saves lives, making C the priority precaution.

Correct Answer: C

Rationale: Glyceryl trinitrate (GTN) relieves effort angina primarily by reducing preload (venodilation) and afterload (arterial dilation), decreasing myocardial oxygen demand, a true and major mechanism. It doesn't primarily reduce coronary vasospasm (more relevant in variant angina), nor significantly affect the renin-angiotensin system in this context. While it causes some coronary vasodilation, this is secondary to systemic effects on demand reduction. It doesn't cause systemic vasoconstriction (opposite effect). The preload/afterload reduction is the cornerstone of GTN's efficacy in stable angina, improving oxygen supply-demand balance, a critical concept in ischemic heart disease management.

Correct Answer: B

Rationale: Lithium levels rise with drugs reducing renal clearance or altering metabolism. St John's wort induces CYP enzymes, potentially lowering lithium (not renally metabolized). Ibuprofen, an NSAID, reduces renal lithium excretion by inhibiting prostaglandins, increasing plasma levels, a well-known interaction. Phenytoin induces metabolism but doesn't affect lithium's renal clearance. Haloperidol and sertraline have minimal pharmacokinetic impact on lithium. Ibuprofen's effect necessitates monitoring, as elevated lithium risks toxicity (e.g., tremor, confusion), critical in bipolar management.

Correct Answer: D

Rationale: Metformin is a medication commonly used to treat type 2 diabetes. It exerts its action through multiple mechanisms, as outlined below:

Correct Answer: B

Rationale: The area where the highest percentage of sodium and water are reabsorbed back into the bloodstream is the proximal tubule. In the nephron, the proximal tubule is responsible for reabsorbing approximately 65-70% of filtered sodium and water. This reabsorption is crucial for maintaining the body's electrolyte balance and blood volume. The proximal tubule is lined with specialized cells that actively transport sodium ions out of the tubular fluid, creating an osmotic gradient that allows for passive reabsorption of water. This efficient reabsorption process helps to ensure that essential substances are conserved while waste products are excreted in the urine.