ATI RN
ATI Pharmacology Practice A Questions
Question 1 of 5
The most serious adverse effect of tricyclic antidepressant (TCA) overdose is:
Correct Answer: B
Rationale: Tricyclic antidepressants (TCAs) are associated with a high risk of toxicity in overdose, with cardiac arrhythmias being the most serious and life-threatening complication. TCAs can block sodium channels in the heart, leading to prolonged QRS intervals, ventricular tachycardia, and even cardiac arrest. Hyperpyrexia, seizures, and metabolic acidosis can also occur, but cardiac arrhythmias are the primary concern due to their potential to cause sudden death. Immediate medical intervention is required to manage TCA overdose, including cardiac monitoring and administration of sodium bicarbonate.
Question 2 of 5
The nurse is caring for a client receiving isoniazid (INH) for tuberculosis. Which instruction should the nurse include?
Correct Answer: C
Rationale: Isoniazid treats TB but risks hepatotoxicity, causing jaundice (yellowing skin, choice C), a serious sign needing immediate reporting to prevent liver failure. Food is optional'INH can be taken either way. Tyramine relates to MAOIs, not INH. Bedtime isn't specific'dosing is flexible. Reporting jaundice aligns with INH's side effect profile, critical in TB therapy where long-term use is common, making C the essential instruction for early detection and safety.
Question 3 of 5
When administering heparin subcutaneously, the nurse will follow which procedure?
Correct Answer: D
Rationale: When administering heparin subcutaneously, the nurse should use a - to -inch, 25- to 30-gauge needle to inject the medication into the subcutaneous tissue. This needle size is appropriate for delivering the medication effectively and safely in the subcutaneous layer rather than deeper into the muscle. Using the correct needle size helps ensure proper absorption and reduces the risk of complications such as bleeding or bruising at the injection site.
Question 4 of 5
Which class of targeted therapy would cause the nurse the most concern in regard to a possible infusion reaction?
Correct Answer: C
Rationale: Monoclonal antibodies, such as trastuzumab and rituximab, are more likely to cause infusion reactions compared to other classes of targeted therapy. These reactions can range from mild symptoms like fever and chills to severe anaphylaxis. Tyrosine kinase inhibitors, multikinase inhibitors, and proteasome inhibitors are less commonly associated with infusion reactions. The nurse should closely monitor patients receiving monoclonal antibodies during infusion and be prepared to manage any adverse reactions promptly.
Question 5 of 5
The pharmacokinetic elimination half-life of the following drugs mirrors their pharmacodynamic duration and intensity of action:
Correct Answer: C
Rationale: Dobutamine's pharmacodynamic effects closely match its short half-life, as it is rapidly metabolized and its action declines quickly.