The most important reason for highly restricted use of penicillin G injections in present-day therapeutics is its

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Question 1 of 5

The most important reason for highly restricted use of penicillin G injections in present-day therapeutics is its

A. Narrow spectrum of activity B. Potential to cause hypersensitivity reaction C. Short duration of action D. Neurotoxicity

Correct Answer: B

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Question 2 of 5

Amoxicillin + Clavulanic acid is active against the following organism except

A. Methicillin resistant Staph. aureus B. Penicillinase producing Staph. aureus C. Penicillinase producing N. gonorrhoeae D. Î²-lactamase producing E. coli

Correct Answer: A

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Question 3 of 5

The most important mechanism by which tetracycline antibiotics exert antimicrobial action is

A. They chelate CaÂ²âº ions and alter permeability of bacterial cell membrane B. They bind to 30S ribosomes and inhibit bacterial protein synthesis C. They bind to 50S ribosomes and interfere with translocation of the growing peptide chain in the bacteria D. They interfere with DNA mediated RNA synthesis in bacteria

Correct Answer: B

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Question 4 of 5

Compared to older tetracyclines, doxycycline produces a lower incidence of superinfection diarrhoea because

A. It is completely absorbed in the small intestines so that drug concentration in the colonic contents is low B. It is inactivated by the gut microflora C. It is not active against the microbes of the normal gut flora D. It is a potent tetracycline and inhibits the superinfection causing microbes as well

Correct Answer: A

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Question 5 of 5

The most important mechanism by which gram-negative bacilli acquire chloramphenicol resistance is

A. Decreased permeability into the bacterial cell B. Acquisition of a plasmid encoded for chloramphenicol acetyl transferase C. Lowered affinity of the bacterial ribosome for chloramphenicol D. Switching over from ribosomal to mitochondrial protein synthesis

Correct Answer: B

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

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