The most cardiac manifestation of glycosides intoxication is:

Correct Answer: D

Rationale: The correct answer is D because glycosides intoxication can lead to a range of cardiac manifestations, including atrioventricular junctional rhythm, second-degree atrioventricular blockade, and ventricular tachycardia. These effects are due to the toxic effects of glycosides on the heart's electrical conduction system. Atrioventricular junctional rhythm occurs when the impulse originates in the atrioventricular node, leading to a slower heart rate. Second-degree atrioventricular blockade involves a delay or interruption in the electrical signals between the atria and ventricles. Ventricular tachycardia is a rapid heart rhythm originating in the ventricles. Therefore, all of the above options are correct manifestations of glycosides intoxication.

Correct Answer: B

Rationale: Step-by-step rationale: 1. Digoxin is a positive inotropic drug of glycoside structure. 2. Digoxin works by inhibiting the sodium-potassium pump, leading to increased intracellular calcium levels, enhancing myocardial contractility. 3. Dopamine is a catecholamine used for its positive inotropic effects but does not have a glycoside structure. 4. Dobutamine is a synthetic catecholamine with positive inotropic effects but lacks a glycoside structure. 5. Adrenaline is a catecholamine with positive inotropic effects, but it is not a glycoside structure. Summary: Digoxin is the correct answer because it has a glycoside structure and exerts positive inotropic effects by increasing intracellular calcium levels. Dopamine, dobutamine, and adrenaline are not glycoside drugs and work through different mechanisms.

Correct Answer: D

Rationale: The correct answer is D: For treatment of simple obesity. Thyroid hormones are not indicated for the treatment of simple obesity as they do not directly affect weight loss. A: Cretinism - Thyroid hormones are indicated for the treatment of cretinism, a condition caused by thyroid hormone deficiency in infancy. B: Myxoedema - Thyroid hormones are indicated for the treatment of myxoedema, a severe form of hypothyroidism in adults. C: Hashimoto's disease - Thyroid hormones are indicated for the treatment of Hashimoto's disease, an autoimmune condition that leads to hypothyroidism. In summary, thyroid hormones are indicated for conditions related to thyroid hormone deficiencies and dysfunctions, but not for the treatment of simple obesity.

Correct Answer: A

Rationale: The correct answer is A: Antiprogestin. Mifepristone is a synthetic steroid that acts as an antiprogestin by competitively binding to progesterone receptors, blocking the effects of progesterone. It is commonly used for medical abortion and in the treatment of conditions like Cushing's syndrome. Explanation for incorrect choices: B: Antiandrogen - Mifepristone does have some antiandrogenic properties, but its primary mechanism of action is as an antiprogestin. C: Antiestrogen - Mifepristone is not an antiestrogen; it does not block estrogen receptors. D: Androgen - Mifepristone is not an androgen; it is a synthetic steroid with antiprogestational activity.

Correct Answer: A

Rationale: The correct answer is A. Allergic reaction is a response of the immune system to an allergen that the body has previously been sensitized to. This response can be local or generalized, involving various symptoms such as itching, hives, swelling, and in severe cases, anaphylaxis. Choice B describes inflammation, not specifically related to allergies. Choices C and D are unrelated medications. In summary, choice A is correct because it accurately defines an allergic reaction, while the other choices do not specifically address the nature of allergies.