ATI RN
Pediatric Immunizations NCLEX Questions Questions
Question 1 of 5
The membrane attack complex (MAC) uses C3 to activate the final part of the complement pathway. It is important in defense against Neisseria. Which of the following components is/are inserted into the plasma membrane of the target cell, allowing for free passage of water/solute and thus killing the cell?
Correct Answer: D
Rationale: C5b-C9 form the MAC, with C9 polymerizing to lyse the target cell.
Question 2 of 5
Increases vascular permeability
Correct Answer: B
Rationale: Histamine, released by mast cells, increases vascular permeability, aiding immune cell infiltration to the site of infection.
Question 3 of 5
Natural killer cell receptors NKG2/CD94 and killer inhibitory receptors allow for the killing of antibodies in the presence of:
Correct Answer: D
Rationale: NK cells kill when MHC class I is absent or reduced, as inhibitory receptors are not engaged.
Question 4 of 5
Which of the following subunit vaccines is recommended for children but not adults?
Correct Answer: B
Rationale: Hib vaccine is routinely given to children to prevent meningitis, not typically required for adults.
Question 5 of 5
A child presents with recurrent infections with bacteria, fungi, and viruses. The resident asks the attending physician about IL-2R gamma chain mutations, as the patient is a male. The attending physician makes a diagnosis and begins writing orders for bone marrow transplantation and possible gene therapy. Which of the following does the patient have?
Correct Answer: D
Rationale: SCID, often X-linked due to IL-2Rγ mutations, causes severe infections and requires bone marrow transplantation.