ATI RN
Drugs Affecting the Cardiovascular and Renal Systems Edapt Quizlet Questions
Question 1 of 5
The mechanism of fluoroquinolones’ action is:
Correct Answer: B
Rationale: The correct answer is B: Inhibition of DNA gyrase. Fluoroquinolones target DNA gyrase, an enzyme involved in bacterial DNA replication and repair. By inhibiting DNA gyrase, fluoroquinolones prevent bacterial DNA from unwinding and replicating, ultimately leading to bacterial cell death. Explanation of other choices: A: Inhibition of phospholipase C - This is incorrect as fluoroquinolones do not target phospholipase C. C: Inhibition of bacterial cell synthesis - While fluoroquinolones do affect bacterial cell synthesis indirectly by inhibiting DNA gyrase, this is not the primary mechanism of action. D: Alteration of cell membrane permeability - This is incorrect as fluoroquinolones primarily target DNA gyrase, not cell membrane permeability.
Question 2 of 5
Which of the following pairs of drugs would be appropriate for a patient with hypertrophic cardiomyopathy?
Correct Answer: A
Rationale: The correct answer is A: Isosorbide mononitrate and nifedipine. Isosorbide mononitrate is a vasodilator that reduces the workload on the heart, beneficial for hypertrophic cardiomyopathy. Nifedipine is a calcium channel blocker that helps relax the heart muscle. Nitroglycerin (B and C) and captopril (B) are not commonly used in hypertrophic cardiomyopathy. Verapamil (C) can worsen symptoms in some patients with hypertrophic cardiomyopathy. Metoprolol (D) is a beta-blocker that may be used in some cases but is not as effective as nifedipine for this condition.
Question 3 of 5
Which of the following antiarrhythmic drugs would be absolutely contraindicated for this patient?
Correct Answer: C
Rationale: The correct answer is C: Quinidine. Quinidine is contraindicated due to its potential to prolong the QT interval, leading to serious arrhythmias like Torsades de Pointes. Mexiletine and Lidocaine are sodium channel blockers with lower risk of QT prolongation. Phenytoin is an anti-seizure drug and does not typically impact cardiac conduction. Therefore, Quinidine is the absolute contraindication for this patient.
Question 4 of 5
In patients with chronic granulomatous disease which of the following agents increases the synthesis of tumor necrosis factor, leading to activation of phagocytosis?
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 5 of 5
The following drug is used to reduce the frequency of angina pectoris as well as to terminate an acute attack
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.