ATI RN
Peter Attia Drugs Cardiovascular PCSK9 Questions
Question 1 of 5
The mechanism of atropine action is:
Correct Answer: B
Rationale: The correct answer is B: Competitive muscarinic blockade. Atropine is an anticholinergic drug that works by competitively blocking muscarinic receptors, leading to inhibition of parasympathetic nervous system activity. This results in effects such as increased heart rate and dilated pupils. A: Competitive ganglion blockade is incorrect as atropine does not act on ganglionic receptors. C: Competitive neuromuscular blockade is incorrect as atropine does not affect neuromuscular junctions. D: Noncompetitive neuromuscular blockade is incorrect as atropine does not act in a noncompetitive manner on neuromuscular receptors.
Question 2 of 5
Indicate the sympathomimetic agent, which is combined with a local anesthetic to prolong the duration of infiltration nerve block:
Correct Answer: A
Rationale: Step-by-step rationale: 1. Epinephrine is a sympathomimetic agent that constricts blood vessels, reduces bleeding, and prolongs the effect of local anesthetics. 2. By vasoconstriction, epinephrine delays systemic absorption of the anesthetic, leading to a longer duration of action. 3. Xylometazoline is a nasal decongestant, not used for nerve blocks. 4. Isoproterenol and dobutamine are primarily used for cardiac conditions, not for local anesthesia. Summary: Epinephrine is the correct choice due to its vasoconstrictive properties prolonging the effect of local anesthetics. Xylometazoline, Isoproterenol, and Dobutamine are incorrect as they do not serve the same purpose in nerve blocks.
Question 3 of 5
Which of the following drugs has both alfa1-selective and beta-blocking effects?
Correct Answer: A
Rationale: The correct answer is A: Labetalol. Labetalol is a non-selective beta blocker with additional alpha-1 blocking properties. This combination of alpha-1 and beta-blocking effects makes it unique among the choices. Alpha-1 blockade helps reduce peripheral vascular resistance, while beta-blocking action decreases heart rate and contractility. This dual mechanism makes labetalol effective in treating hypertension. Betaxolol (B) is a selective beta-1 blocker, Propranolol (C) is a non-selective beta blocker, and Timolol (D) is a non-selective beta blocker as well. These choices lack the alpha-1 blocking effect present in labetalol, making them incorrect for this question.
Question 4 of 5
Indicate the usual cause of death due to overdose of hypnotics:
Correct Answer: A
Rationale: The correct answer is A, depression of the medullar respiratory center. Hypnotics can suppress the central nervous system, leading to respiratory depression, which can result in death. This is the most common cause of death in hypnotic overdoses. B: Hypothermia is not a usual cause of death in hypnotic overdoses. C: Cerebral edema is not a direct result of hypnotic overdose and would not typically be the cause of death. D: Status epilepticus is not a typical outcome of hypnotic overdose and would not directly lead to death in this context.
Question 5 of 5
Which neurons are involved in parkinsonism?
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.