The major side effect of cholestyramine is hepatotoxicity. This consideration is:

Correct Answer: B

Rationale: Step-by-step rationale: 1. Cholestyramine is a bile acid sequestrant used to lower cholesterol. 2. The major side effects of cholestyramine are gastrointestinal disturbances, not hepatotoxicity. 3. Therefore, the statement that hepatotoxicity is a major side effect is FALSE. 4. Option B is the correct answer as it accurately reflects the lack of hepatotoxicity with cholestyramine. Summary: - Option A is incorrect because hepatotoxicity is not a major side effect of cholestyramine. - Option C "All" is incorrect as it implies that all statements are true, which is not the case. - Option D "None" is incorrect as there is a major side effect associated with cholestyramine, just not hepatotoxicity.

Correct Answer: A

Rationale: The correct answer is A: Hydrochlorothiazide (HydroDiuril). It is a thiazide diuretic that inhibits sodium reabsorption in the distal convoluted tubule, leading to decreased calcium excretion in urine. Amiloride (B) inhibits sodium reabsorption in the collecting duct but does not affect calcium excretion. Furosemide (C) acts on the loop of Henle to inhibit sodium and calcium reabsorption, increasing calcium excretion. Acetazolamide (D) is a carbonic anhydrase inhibitor that increases calcium excretion by causing metabolic acidosis and reducing calcium reabsorption.

Correct Answer: B

Rationale: The correct answer is B: Penicillin V. Penicillin V is gastric acid-resistant due to its stability against the acidic environment of the stomach, allowing it to be absorbed intact in the intestine. Penicillin G (choice A) is not acid-resistant and is inactivated by gastric acid. Carbenicillin (choice C) and Procain penicillin (choice D) are not designed to be acid-resistant and would be inactivated in the stomach as well. Penicillin V is the only option that can withstand the acidic conditions of the stomach, making it the correct choice in this scenario.

Correct Answer: D

Rationale: The correct answer is D: Streptomycin. First-line antimycobacterial drugs are those recommended as initial treatment for Mycobacterium tuberculosis infections. Streptomycin is considered a second-line drug due to its potential for serious side effects and development of resistance. Rifampin, Pyrazinamide, and Isoniazid are all first-line drugs supported by extensive clinical evidence and are preferred for initial therapy. Streptomycin is reserved for cases where first-line drugs are contraindicated or ineffective. Therefore, choosing Streptomycin as the correct answer is logical based on its classification as a second-line antimycobacterial drug.

Correct Answer: B

Rationale: The correct answer is B: Rimantadine. Rimantadine is a derivative of adamantane due to its molecular structure containing an adamantane core. This structural similarity allows rimantadine to exert antiviral activity against influenza A viruses by inhibiting the viral uncoating process. Didanozine (A) is a nucleoside reverse transcriptase inhibitor used in HIV treatment, not related to adamantane. Gancyclovir (C) and Foscarnet (D) are antiviral drugs used for treating herpesvirus infections and cytomegalovirus infections, respectively, but they are not derivatives of adamantane.