ATI RN
Pediatric Genetic Questions
Question 1 of 5
The main gatekeeper for FAP colon cancer is most likely:
Correct Answer: A
Rationale: APC (adenomatous polyposis coli) is the primary gatekeeper gene in familial adenomatous polyposis, initiating polyp formation when mutated.
Question 2 of 5
Most carcinogens are also mutagens:
Correct Answer: A
Rationale: True. Most carcinogens (e.g., UV, tobacco smoke) cause cancer by inducing DNA mutations.
Question 3 of 5
Normal human eggs have:
Correct Answer: A
Rationale: Human eggs (haploid) have 23 chromosomes: 22 autosomes + 1 sex chromosome (X).
Question 4 of 5
Male breast cancer is associated with mutations in:
Correct Answer: B
Rationale: BRCA2 mutations increase male breast cancer risk more than BRCA1.
Question 5 of 5
The proportion of babies that have an abnormality identifiable at birth is:
Correct Answer: B
Rationale: Approximately 2-3% (1 in 33-50) of newborns have a major congenital anomaly.