The initial screening laboratory evaluation of a child with recurrent infections for possible immunodeficiency includes all of the following EXCEPT

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Pediatric Immune Disorder Test Questions Questions

Question 1 of 5

The initial screening laboratory evaluation of a child with recurrent infections for possible immunodeficiency includes all of the following EXCEPT

Correct Answer: D

Rationale: The NBT test is a specific diagnostic test for CGD, not part of initial screening. CBC, lymphocyte count, and immunoglobulin levels are broad screening tools for immunodeficiency.

Question 2 of 5

Failure to thrive, diarrhea, malabsorption, and infections with opportunistic infections (i.e., fungi, Candida sp, Pneumocystis jiroveci [carinii]) suggest

Correct Answer: C

Rationale: T-cell defects lead to impaired cellular immunity, increasing susceptibility to opportunistic infections like fungi and Pneumocystis jiroveci.

Question 3 of 5

A 5-month-old infant presented with reluctance to feed, lethargy, abdominal distension, and severe gingivitis. The parents are healthy relatives and gave history of non-purulent omphalitis with separation of umbilical stump at the age of 2 months. His peripheral smear showed neutrophil count 24,000/mm3. Of the following, the MOST likely diagnosis is

Correct Answer: D

Rationale: Leukocyte adhesion deficiency causes delayed umbilical cord separation, high neutrophil counts, and non-purulent infections due to impaired migration.

Question 4 of 5

Which of the following Antibodies occurs as a pentameric structure?

Correct Answer: A

Rationale: IgM is the only antibody that naturally occurs as a pentamer, consisting of five monomeric units linked by a J chain, enhancing its ability to bind multiple antigens simultaneously.

Question 5 of 5

Endothelial cells expresses glycoprotein that binds with low affinity to WBCs and helps in their recruitment from blood to tissues

Correct Answer: A

Rationale: E-selectin on endothelial cells binds to sialyl Lewis X on leukocytes, facilitating low-affinity rolling during recruitment.

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