ATI RN
The Cardiovascular Pharmacology of Nonsteroidal Anti-Inflammatory Drugs Questions
Question 1 of 5
The indication for interferon gamma administration is:
Correct Answer: C
Rationale: Interferon gamma is indicated for Chronic Granulomatous Disease (CGD) due to its role in enhancing the immune response against intracellular pathogens. CGD is a genetic disorder where phagocytes are unable to produce reactive oxygen species, leading to recurrent infections. Interferon gamma helps activate macrophages to improve host defense against pathogens in CGD patients. Incorrect choices: A: Idiopathic nephrotic syndrome - Interferon gamma is not indicated for this condition as it is primarily used for immune modulation, not for kidney-related issues. B: Hepatitis C virus infection - While interferon alpha is used for hepatitis C, interferon gamma is not the primary treatment for this viral infection. D: Hairy cell leukemia - Interferon alpha is the preferred treatment for hairy cell leukemia, not interferon gamma.
Question 2 of 5
When used alone, the bile acid-binding resins are contraindicated in patients with hypertriglyceridemia. This consideration is:
Correct Answer: A
Rationale: The correct answer is A: TRUE. Bile acid-binding resins can worsen hypertriglyceridemia by increasing triglyceride levels. This is due to the compensatory increase in hepatic triglyceride synthesis. Choice B is incorrect because it contradicts this established fact. Choice C is incorrect as it implies all options are true, which is not the case. Choice D is incorrect as it suggests that none of the options are true, which is also not accurate.
Question 3 of 5
Route of administration of dihydrotachysterol is:
Correct Answer: C
Rationale: The correct answer is C: Oral. Dihydrotachysterol is a form of vitamin D used to treat hypoparathyroidism. The oral route is chosen for its optimal absorption in the gastrointestinal tract. Intravenous (A) and subcutaneous (B) routes are not commonly used for dihydrotachysterol administration due to potential adverse effects and lack of significant benefits. Intranasal (D) administration is not suitable for dihydrotachysterol as it is not designed to be absorbed through the nasal mucosa.
Question 4 of 5
The drug has a steroid-like structure which is responsible for its anti-androgenic effect:
Correct Answer: D
Rationale: The correct answer is D: Spironolactone (Aldactone). Spironolactone has a steroid-like structure due to its chemical similarity to aldosterone, allowing it to competitively inhibit aldosterone receptors. This anti-androgenic effect is crucial in conditions like hirsutism and acne. Amiloride (A), Furosemide (B), and Hydrochlorothiazide (C) do not possess a steroid-like structure and do not exhibit anti-androgenic properties.
Question 5 of 5
Tick the drug belonging to antibiotics-tetracyclines:
Correct Answer: A
Rationale: The correct answer is A: Doxycycline, as it belongs to the tetracycline class of antibiotics. Tetracyclines inhibit bacterial protein synthesis by binding to the bacterial ribosome. Streptomycin (B) is an aminoglycoside, Clarithromycin (C) is a macrolide, and Amoxicillin (D) is a penicillin; these do not belong to the tetracycline class.