ATI RN
Pharmacology of Drugs Acting on Cardiovascular System Questions
Question 1 of 5
The hypothalamic control exists for the thyroid gland. This consideration is:
Correct Answer: A
Rationale: The correct answer is A: TRUE. The hypothalamus secretes thyrotropin-releasing hormone (TRH) which stimulates the anterior pituitary to release thyroid-stimulating hormone (TSH), which in turn stimulates the thyroid gland to produce thyroid hormones. This demonstrates the hypothalamic control over the thyroid gland. Choices B, C, and D are incorrect because the hypothalamus does indeed play a crucial role in regulating the thyroid gland, making the statement true rather than false, all-encompassing, or none at all.
Question 2 of 5
The following statements concerning aspirin are true, EXCEPT:
Correct Answer: C
Rationale: Rationale: C: Aspirin inhibits phospholipase A2. This statement is FALSE. Aspirin does not directly inhibit phospholipase A2. The correct answer is C. Summary: A: TRUE - Aspirin irreversibly inhibits COX. B: TRUE - Aspirin interferes with the chemical mediators of the kallikrein system. D: TRUE - Aspirin inhibits thromboxane A2 formation.
Question 3 of 5
Mechanism of action of sirolimus (rapamycin) is:
Correct Answer: C
Rationale: The correct answer is C: Inhibits calcineurin. Sirolimus inhibits the mTOR pathway by binding to FKBP12 and forming a complex that inhibits the activity of mTOR complex 1. Calcineurin is not directly involved in the mechanism of action of sirolimus. Choice A is incorrect because sirolimus does not involve anti-idiotype antibodies. Choice B is incorrect because sirolimus does not modulate the CD3 receptor. Choice D is incorrect because sirolimus does not mediate ADCC towards T lymphocytes.
Question 4 of 5
Vitamin К enhances the anticoagulant property of coumarins. This statement is:
Correct Answer: B
Rationale: Step 1: Identify the statement - "Vitamin K enhances the anticoagulant property of coumarins." Step 2: Recall that Vitamin K is actually involved in blood clotting, counteracting anticoagulants. Step 3: Understand that coumarins are anticoagulants that work by inhibiting Vitamin K. Step 4: Therefore, the statement is FALSE as Vitamin K doesn't enhance but counteracts coumarins. Summary: Choice A is incorrect because the statement is false, Choice C and D are incorrect as they do not apply to the given scenario.
Question 5 of 5
Nicotinic acid (Niacin) acts by increasing the rate of catabolism of VLDL. This consideration is:
Correct Answer: A
Rationale: The correct answer is A because nicotinic acid (niacin) increases the rate of catabolism of VLDL by inhibiting lipolysis in adipose tissue, leading to decreased free fatty acids available for VLDL synthesis. This results in decreased VLDL production and increased clearance, thus lowering plasma VLDL levels. Option B is incorrect because nicotinic acid does not decrease VLDL catabolism. Option C is incorrect as not all choices are correct. Option D is incorrect as there is a correct answer.