ATI RN
Pediatric Immunization Test Questions Questions
Question 1 of 5
The genes encoding which of the following can undergo hypermutation to create receptors that are an even better fit for foreign antigens?
Correct Answer: A
Rationale: BCRs undergo somatic hypermutation in B cells to enhance antigen affinity, unlike TCRs or MHCs.
Question 2 of 5
Binds antigen
Correct Answer: C
Rationale: The Fab region binds antigens via its variable domains, formed by light and heavy chains.
Question 3 of 5
Pepsin cleaves what region of immunoglobulin?
Correct Answer: C
Rationale: Pepsin cleaves below the hinge region, producing F(ab')2 fragments.
Question 4 of 5
Which of the following is a very sensitive and simple test for antigens, which uses a covalent complex of enzyme linked to antibody, to detect antigen directly or to bind antibody-antigen complex?
Correct Answer: A
Rationale: ELISA uses an enzyme-linked antibody to detect antigens with high sensitivity and simplicity, making it ideal for this purpose.
Question 5 of 5
During the development of B cells, the Ig gene segments are rearranged and brought next to each other to form a contiguous functional gene (somatic recombination). The complex of enzymes involved in somatic recombination in lymphocytes is called:
Correct Answer: C
Rationale: V(D)J-recombinase, including RAG-1 and RAG-2, facilitates somatic recombination in B and T cells.