The following viruses are referred to the Filoviridae family:

Correct Answer: C

Rationale: Step-by-step rationale: 1. The Filoviridae family includes Marburg virus and Ebola virus. 2. Both viruses are characterized by filamentous, enveloped structure. 3. They cause severe hemorrhagic fever in humans. 4. Lassa virus and lymphocytic choriomeningitis viruses belong to Arenaviridae. 5. Chikungunya virus and Sindbis virus are alphaviruses. 6. Crimean-Congo virus and Hantaan virus are bunyaviruses. 7. Therefore, the correct answer is C.

Correct Answer: B

Rationale: The correct answer is B: IgM. IgM antibodies are the first type of antibodies produced in response to an infection, indicating an active or recent infection. In the case of a rubella virus infection in a fetus, IgM antibodies can be detected in the umbilical cord blood, confirming the presence of the virus. IgA antibodies are mainly found in mucosal areas, IgG antibodies indicate past infection or immunity, and IgD antibodies play a role in B cell activation but are not typically detected in this context.

Correct Answer: C

Rationale: Rifampicin is the correct answer because it is a first-line antibiotic for treating pulmonary tuberculosis. It has excellent bactericidal activity and penetrates well into lung tissues where the infection is located. Rifampicin is also known for preventing the development of resistance. Tetracycline (A) and Furasolidone (B) are not commonly used for tuberculosis treatment. Bactrim (D) is a combination of sulfamethoxazole and trimethoprim, not effective for tuberculosis treatment.

Correct Answer: B

Rationale: The correct answer is B: Clostridium perfringens. This bacterium is associated with myonecrosis/gas gangrene and can produce enterotoxin causing food intoxication. Clostridium septicum (A) is associated with wound infections but not known for food intoxications. Clostridium histolyticum (C) is not typically associated with myonecrosis or food intoxications. Clostridium novyi (D) is known for causing black disease in sheep and cattle, not food intoxications.

Correct Answer: B

Rationale: The correct answer is B: Jenner. Edward Jenner performed the first vaccination against smallpox in 1796 by using cowpox virus to immunize individuals. He observed that milkmaids who had contracted cowpox did not get smallpox, leading to the development of the smallpox vaccine. Pasteur is known for germ theory, Semmelweis for handwashing in healthcare, and Koch for identifying the causative agents of diseases. However, none of them performed the first smallpox vaccination like Jenner.

Correct Answer: B

Rationale: The correct answer is B: Treponema pallidum. 1. Treponema pallidum is a spirochete bacterium known to cause syphilis. 2. Borrelia burgdorferi causes Lyme disease, not syphilis. 3. Leptospira interrogans causes leptospirosis, not syphilis. 4. Rickettsia rickettsii causes Rocky Mountain spotted fever, not syphilis. Therefore, Treponema pallidum is the causative agent of syphilis, making it the correct answer.

Correct Answer: D

Rationale: The correct answer is D, Late congenital syphilis. This is because the patient presents with Hutchinson's teeth, which are a characteristic feature of late congenital syphilis. Hutchinson's teeth are small, barrel-shaped teeth with a wider cervix and notched incisors. The patient's history of visual impairment and hearing aid use also support the diagnosis of late congenital syphilis, as these are common manifestations of this stage of the disease. Choice A, Primary syphilis, is incorrect because it typically presents with a painless sore at the site of infection, not dental abnormalities. Choice B, Early congenital syphilis, is incorrect as dental abnormalities in this stage are usually more severe, such as mulberry molars. Choice C, Neurosyphilis, is incorrect as it primarily affects the central nervous system and does not typically present with dental abnormalities.

Correct Answer: C

Rationale: The normal microflora plays a crucial role in defending against pathogens in the skin and mucus. This is because the skin and mucus act as physical barriers and the normal microflora outcompetes potential pathogens, preventing their colonization. In contrast, the circulatory system (A), hepatobiliary tract (B), and CNS (D) are not typically colonized by normal microflora, so they do not directly contribute to defense against pathogens in those areas.

Correct Answer: A

Rationale: The correct answer is A: Neisseria meningitidis. This is because Neisseria meningitidis is a Gram-negative diplococcus that is oxidase-positive and fermentative. Neisseria gonorrhoeae is also a Gram-negative diplococcus, but it is not fermentative. Moraxella catarrhalis is oxidase-positive but not fermentative. Haemophilus influenzae is Gram-negative but is not a diplococcus, and it is not fermentative. Therefore, based on the characteristics provided in the question, Neisseria meningitidis is the most likely causative agent.