ATI RN
Pharmacology CNS Drugs Quiz Questions
Question 1 of 5
The following is a selective COX-3 enzyme inhibitor:
Correct Answer: C
Rationale: Acetaminophen (choice C) is proposed to inhibit COX-3 (a COX-1 variant) in the CNS, explaining its antipyretic and analgesic effects with minimal anti-inflammatory action. Acetylsalicylic acid (choice A) and Diclofenac (choice B) inhibit COX-1 and COX-2, while Celecoxib (choice D) targets COX-2. Acetaminophen's selectivity distinguishes its mechanism, key for fever and pain management.
Question 2 of 5
Psychic depression can be treated by the following:
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 3 of 5
L-Dopa can be used to treat which of the following:
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 4 of 5
Which of the following narcotics has the longest duration of effect?
Correct Answer: A
Rationale: Methadone (choice A), with a half-life of 24-36 hours, has the longest duration among these narcotics, ideal for addiction maintenance. Controlled-release morphine (choice B) lasts 12-24 hours, Levorphanol (choice C) 6-8 hours, and Fentanyl (choice D) 1-2 hours IV. Methadone's pharmacokinetics stand out.
Question 5 of 5
Which one of the following drugs can cause hypotension because it can block alpha-adrenergic receptors on vascular smooth muscle cells?
Correct Answer: D
Rationale: Phenothiazines (choice D), like chlorpromazine, block alpha-adrenergic receptors, causing vasodilation and hypotension. Clozapine (choice A) causes less alpha blockade, Diazepam (choice B) doesn't, and H1 blockers (choice C) cause sedation, not hypotension. This side effect is notable in phenothiazines.