ATI RN
Pharmacology CNS Drugs Quiz Questions
Question 1 of 5
The following is a selective COX-2 enzyme inhibitor:
Correct Answer: C
Rationale: Celecoxib (choice C) selectively inhibits COX-2, reducing inflammation with less GI irritation than non-selective NSAIDs like Aspirin (choice A) and Diclofenac (choice B), which inhibit both COX-1 and COX-2. Paracetamol (choice D) has weak COX inhibition, primarily COX-3, and lacks significant anti-inflammatory action. Celecoxib's selectivity minimizes COX-1-related side effects, making it preferable in patients at risk for GI issues, a key advancement in NSAID therapy.
Question 2 of 5
The following statements about carbidopa is CORRECT:
Correct Answer: A
Rationale: Carbidopa (choice A) inhibits dopa decarboxylase peripherally, preventing L-DOPA breakdown, enhancing CNS delivery in Parkinson's. It doesn't cross the BBB (choice B), reduces L-DOPA dose needs (choice C incorrect), and decreases peripheral metabolism (choice D incorrect). This correct statement underscores its adjunctive role.
Question 3 of 5
Psychic depression can be treated by the following:
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 4 of 5
L-Dopa can be used to treat which of the following:
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 5 of 5
Which of the following narcotics has the longest duration of effect?
Correct Answer: A
Rationale: Methadone (choice A), with a half-life of 24-36 hours, has the longest duration among these narcotics, ideal for addiction maintenance. Controlled-release morphine (choice B) lasts 12-24 hours, Levorphanol (choice C) 6-8 hours, and Fentanyl (choice D) 1-2 hours IV. Methadone's pharmacokinetics stand out.