ATI RN
Chapter 14 Drugs for the Reproductive System Questions
Question 1 of 5
The following glucocorticoid has significant mineralocorticoid activity also:
Correct Answer: A
Rationale: Rationale: 1. Hydrocortisone is a natural glucocorticoid with significant mineralocorticoid activity. 2. It binds to both glucocorticoid and mineralocorticoid receptors. 3. This dual activity can lead to sodium retention and potassium excretion. 4. Triamcinolone, Dexamethasone, and Betamethasone are synthetic glucocorticoids with minimal mineralocorticoid effects. Summary: - Triamcinolone, Dexamethasone, and Betamethasone have negligible mineralocorticoid activity. - Hydrocortisone stands out due to its substantial mineralocorticoid effects alongside its glucocorticoid actions.
Question 2 of 5
After chronic systemic therapy, withdrawal of corticosteroids should be gradual because:
Correct Answer: B
Rationale: The correct answer is B: Abrupt withdrawal may reactivate the underlying disease. When corticosteroids are used chronically, the body's natural production of cortisol is suppressed. Abruptly stopping corticosteroid therapy can lead to adrenal insufficiency and potentially reactivate the underlying disease due to the sudden drop in cortisol levels. Option A is incorrect because corticosteroids do not produce psychological dependence. Option C is incorrect as rebound hypertension is not a typical consequence of corticosteroid withdrawal. Option D is incorrect as only option B is directly related to the physiological consequences of abrupt corticosteroid withdrawal.
Question 3 of 5
For the treatment of hypogonadism and impotence, testosterone/dihydrotestosterone can be administered by the following route/routes:
Correct Answer: D
Rationale: The correct answer is D because testosterone and dihydrotestosterone are typically administered through intramuscular or transdermal routes. Intramuscular injection ensures direct delivery into the bloodstream, while transdermal patches allow for gradual absorption through the skin. Oral administration is not preferred due to liver metabolism. Therefore, options A and C alone are not sufficient. The combination of both intramuscular (B) and transdermal (C) routes provides effective and reliable delivery for treating hypogonadism and impotence.
Question 4 of 5
The following is not a legitimate indication for the use of anabolic steroids:
Correct Answer: A
Rationale: The correct answer is A. Anabolic steroids are not legitimate for enhancing sports performance due to ethical and health risks. Suboptimal growth in children, senile osteoporosis, and hypoplastic anemia are valid medical uses of anabolic steroids. Sports performance enhancement can lead to unfair competition, health issues, and legal implications.
Question 5 of 5
The following drug has potent antiandrogenic and weak progestational activity:
Correct Answer: C
Rationale: The correct answer is C: Cyproterone acetate. Cyproterone acetate is a potent antiandrogen due to its ability to competitively block androgen receptors. It also exhibits weak progestational activity, making it effective in treating conditions like hirsutism and acne. Ethylestrenol (A) is an anabolic steroid, Clomiphene citrate (B) is a selective estrogen receptor modulator, and Magestrol acetate (D) is a progestin with no antiandrogenic properties.