The following factors are implicated in the pathogenesis of type 1 DM EXCEPT

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Pediatric Endocrine System Questions

Question 1 of 5

The following factors are implicated in the pathogenesis of type 1 DM EXCEPT

Correct Answer: D

Rationale: Excessive infection exposure (D) is not a risk factor; limited exposure may increase autoimmunity risk.

Question 2 of 5

Guidelines suggest that diabetic patients should commence screening for celiac disease

Correct Answer: A

Rationale: Celiac screening is recommended at diagnosis (A) for T1DM due to high co-prevalence.

Question 3 of 5

When diabetes and thyroid disease coexist, the possibility of autoimmune adrenal insufficiency should be considered. It may be heralded by the followings EXCEPT

Correct Answer: A

Rationale: Increasing insulin requirements (A) suggest better insulin sensitivity, not adrenal insufficiency, which reduces insulin needs.

Question 4 of 5

You suspect a metabolic problem in a 30-day-old girl presented with poor feeding, vomiting, lethargy, and convulsion. Previous sibling died with the same condition. Serum ammonia, pH, HCO3, and anion gap are normal. Of the following, the MOST likely diagnosis is

Correct Answer: D

Rationale: Normal ammonia, pH, and anion gap with neonatal symptoms and family history suggest an aminoacidopathy (e.g., nonketotic hyperglycinemia), not porphyria (A), galactosemia (B), organic acidemia (C), or urea cycle defect (D), which alter these parameters.

Question 5 of 5

A 4-month-old boy presented with failure to thrive, rapid breathing, and repeated vomiting. On examination, there is hepatomegaly and abdominal sonography revealed renal calcification. Of the following, the MOST likely urine odor of this infant is

Correct Answer: D

Rationale: Tyrosinemia type 1, with hepatomegaly, failure to thrive, and renal issues, produces a boiled cabbage urine odor from tyrosine metabolites, unlike other disorders (A, B, C, E).

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