ATI RN
ATI Pharmacology Practice B 2023 Questions
Question 1 of 5
The following drugs undergo significant enterohepatic circulation:
Correct Answer: A
Rationale: Oestrogens undergo enterohepatic circulation as they are conjugated in the liver, excreted in bile, and reabsorbed in the intestine, prolonging their action.
Question 2 of 5
A 19-year-old man attempts suicide after failing all of his college courses. He goes home and takes more than 90 digoxin tablets (0.25 mg each), ingesting them about 3 h prior to presentation at the emergency department. He is brought to the hospital by his brother. Vital signs are as follows: pulse is 50 beats/minute, and the electrocardiogram indicates third-degree heart block. Serum electrolytes are normal. Which of the following is the most important therapy to initiate in this patient?
Correct Answer: B
Rationale: Digoxin overdose (bradycardia, heart block) requires digoxin immune Fab , binding free digoxin to reverse toxicity. Amiodarone and lidocaine treat arrhythmias but not the cause. Potassium and verapamil (E) worsen hyperkalemia or block. Fab is urgent here.
Question 3 of 5
A client with bipolar disorder is prescribed lithium carbonate. Which symptom should the nurse teach the client to report?
Correct Answer: C
Rationale: Lithium stabilizes mood but risks toxicity (e.g., >1.5 mEq/L), causing tremors , a neurologic sign needing reporting to adjust dosing or check levels. Thirst and weight gain are common, manageable. Nausea occurs but is less urgent unless severe. Tremors indicate potential overdose, critical in bipolar disorder where narrow therapeutic range demands vigilance, making C the key symptom to report.
Question 4 of 5
The nurse reviews the list of medications and is aware that red blood cell production can be stimulated with which drug for anemia?
Correct Answer: A
Rationale: Epoetin alfa is a recombinant form of erythropoietin, a hormone that stimulates red blood cell production. It is used to treat anemia, particularly in patients with chronic kidney disease or those undergoing chemotherapy. Filgrastim and sargramostim stimulate white blood cell production, while interleukin 2 is used to boost the immune system. The nurse should recognize epoetin alfa as the appropriate drug for managing anemia and monitor the patient's hemoglobin levels during treatment.
Question 5 of 5
Which of the following describes the relationship of the blood concentration attained with initial dosing and the dose of drug given
Correct Answer: C
Rationale: The relationship of the blood concentration attained with initial dosing and the dose of drug given is best described by the concept of steady state. Steady state refers to the point at which the rate of drug input (dose) equals the rate of drug elimination, resulting in consistent drug levels in the blood. Achieving steady state typically requires several half-lives of the drug, during which the drug concentration gradually increases with each dose until it stabilizes. The dose of the drug given will influence how quickly steady state is reached and at what concentration the drug will be maintained in the body. Factors such as bioavailability, half-life, volume of distribution, and clearance play important roles in determining the dosage needed to reach and maintain steady state drug levels in the body.