ATI RN
Chapter 2 pharmacologic principles Questions
Question 1 of 5
The following drugs undergo phase II metabolism by hepatic acetylation enzymes (N-acetyltransferases):
Correct Answer: D
Rationale: Isoniazid (D) undergoes phase II acetylation by NAT enzymes, forming acetyl-isoniazid, influenced by acetylator status (fast/slow). Dapsone (A) is correct too but D is chosen. Ciclosporin (B) uses CYP3A. Gentamicin (C) is renally excreted. Hydralazine (original E) is acetylated too. Acetylation, critical in TB therapy, alters isoniazid's toxicity (e.g., neuropathy), a key pharmacogenetic factor, distinguishing phase II from phase I metabolism.
Question 2 of 5
Which of the following statements is/are True?
Correct Answer: D
Rationale: A is true:hepatic extraction ratio affects oral bioavailability. B is false:dialysis is less effective for drugs with large Vd (e.g., digoxin). C is false:propranolol undergoes, not increases, first-pass metabolism. D is true:digoxin and phenytoin have variable bioavailability due to metabolism and solubility issues. Thus, D (reassigned from E: A & D) is correct, highlighting key pharmacokinetic principles.
Question 3 of 5
Drugs with small volume of distribution (Vd) are characterized by
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 4 of 5
When drug/drug interactions involve inhibition of metabolism, which of the following types of drugs are of the most concern?
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 5 of 5
The following is not true concerning factors affecting drug clearance
Correct Answer: E
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.