The following criteria are needed for the diagnosis of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) EXCEPT

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Pediatric Endocrine System Questions

Question 1 of 5

The following criteria are needed for the diagnosis of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) EXCEPT

Correct Answer: B

Rationale: SIADH requires hyponatremia with low serum osmolality (not normal, as in B), high urine osmolality (C), high urinary sodium (A), normal organ function (D), and euvolemia (E).

Question 2 of 5

Reported side effects of GH treatment include the following EXCEPT

Correct Answer: D

Rationale: GH does not increase type 1 DM risk 6-fold (E); other side effects (A-D) are documented.

Question 3 of 5

Precocious puberty in girls is defined by the onset of secondary sexual characteristics before the age of

Correct Answer: B

Rationale: Precocious puberty in girls is defined as onset before age 8 (B), per endocrine guidelines.

Question 4 of 5

The thyroid hormones are transported in plasma bound to thyroxine-binding globulin (TBG), a glycoprotein synthesized in the liver. TBG binds approximately 70% of T4 and 50% of T3. TBG level increase with administration of

Correct Answer: A

Rationale: Estrogens (A) increase TBG levels, raising bound thyroid hormone.

Question 5 of 5

Levothyroxine (I-T4) given orally is the treatment of choice in congenital hypothyroidism. The recommended initial starting dose is

Correct Answer: D

Rationale: Initial dose for congenital hypothyroidism is 10-15 μg/kg/day (E) to normalize T4 quickly.

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