ATI RN
ATI Pharmacology Exam Practice Questions
Question 1 of 5
The following are true for adrenaline EXCEPT:
Correct Answer: C
Rationale: Adrenaline, or epinephrine, is a catecholamine that exerts its effects through adrenergic receptors, which are G-protein-coupled, making its action via G-proteins a true statement. Alpha receptor stimulation typically inhibits adenylate cyclase, reducing cyclic AMP (cAMP) production, which aligns with its known pharmacology and is also true. Adrenaline can indeed be administered via inhalation (e.g., for asthma), orally (though less common), and parenterally (e.g., intramuscularly in anaphylaxis), confirming this as true. However, adrenaline does have active metabolites, such as metanephrine and normetanephrine, produced via catechol-O-methyltransferase (COMT) metabolism, making the statement about having no active metabolites false. In cardiac arrest, it facilitates CPR by causing peripheral vasoconstriction, increasing coronary perfusion pressure, which is true. The false statement here is about the absence of active metabolites, as adrenaline's breakdown products retain some activity, a key point in understanding its pharmacokinetics and duration of effect.
Question 2 of 5
Advil, Motrin, and Nuprin are examples of
Correct Answer: C
Rationale: Advil, Motrin, and Nuprin are trade (brand) names for ibuprofen, marketed by different companies, distinct from its generic name (ibuprofen) or chemical name (e.g., 2-(4-isobutylphenyl)propanoic acid). Combination names aren't a category. Trade names reflect commercial branding, familiar to clients, a key distinction in pharmacology.
Question 3 of 5
The adolescent is supposed to go to the school nurse at 12:00 to receive his medication for attention-deficit hyperactivity disorder (ADHD). He often does not go for the medication. What best describes the nurse's understanding of this situation?
Correct Answer: A
Rationale: Adolescents prioritize peer image-skipping ADHD meds (e.g., Ritalin) at school likely stems from embarrassment, a developmental trait. Lack of understanding or forgetting is possible but less likely with routine. Conscious refusal needs evidence (e.g., verbal rejection). Embarrassment fits social sensitivity, guiding intervention.
Question 4 of 5
Which drug type is often used as a first-line treatment for depression due to its side effect profile?
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 5 of 5
Recent studies into the pathogenesis of halothane-induced malignant hyperthermia indicate which of the following as the likely implicating cause?
Correct Answer: B
Rationale: Malignant hyperthermia (MH) from halothane involves excitation-contraction coupling defects . MH, a genetic disorder, stems from ryanodine receptor (RYR1) mutations, causing uncontrolled calcium release in muscle, not drug toxicity . Sodium defects , oxygen deficits , or neural overmodulation (E) aren't implicated. This coupling defect triggers hypermetabolism, explaining MH's rapid onset with halothane exposure.