ATI RN
ATI RN Pharmacology Online Practice 2023 B Questions
Question 1 of 5
The following are metabolized by enzymes in the hepatic smooth endoplasmic reticulum:
Correct Answer: C
Rationale: Metoprolol is metabolized primarily by hepatic enzymes in the smooth endoplasmic reticulum via CYP450 pathways.
Question 2 of 5
A 43-year-old woman with multiple sclerosis has not been treated with medication because of only having mild symptoms. Now, she has bilateral lower extremity weakness and urinary complaints. She has begun on mitoxantrone. Which of the following adverse effects must the treating physician be aware of?
Correct Answer: B
Rationale: Mitoxantrone for MS progression risks hepatitis . This chemotherapeutic damages liver cells, requiring monitoring. Anxiety , hypopyrexia , muscle strength , and leukocytosis (E) aren't primary. Hepatotoxicity, with cardiotoxicity, is a key concern in this worsening MS case.
Question 3 of 5
Tricyclic antidepressants
Correct Answer: B
Rationale: Tricyclic antidepressants (TCAs) like imipramine block norepinephrine and serotonin reuptake, but their anticholinergic effects are significant. In glaucoma, particularly angle-closure type, these effects can increase intraocular pressure by dilating pupils and obstructing aqueous humor outflow, risking acute attacks—thus, they're contraindicated. TCAs lower seizure threshold, lacking anticonvulsant activity, and may exacerbate epilepsy. They don't enhance levodopa absorption; rather, they might interact via monoamine pathways, but this isn't a primary effect. Some TCAs (e.g., amitriptyline) have quinidine-like sodium channel blockade, giving antiarrhythmic properties, but this isn't their primary use. The glaucoma concern is critical due to the anticholinergic mechanism, making it a key clinical consideration and the most accurate statement here.
Question 4 of 5
A patient asks the nurse for information about fat-soluble vitamins. What is the nurse's best response?
Correct Answer: C
Rationale: Fat-soluble vitamins (A, D, E, K) are stored in the liver and adipose tissue and excreted slowly, making them more likely to accumulate and cause toxicity if taken in excess. They are not metabolized rapidly (A) and can be stored in the liver (B). They can be toxic (D) if consumed in large amounts.
Question 5 of 5
A patient who has been taking antihypertensive drugs for a few months complains of having a persistent dry cough. The nurse knows that this cough is an adverse effect of which class of antihypertensive drugs?
Correct Answer: B
Rationale: The persistent dry cough mentioned by the patient is a well-known adverse effect of ACE inhibitors. This side effect is due to the accumulation of bradykinin in the lungs, leading to irritation and stimulation of cough receptors. If a patient taking an ACE inhibitor develops a persistent dry cough, it is essential to notify the healthcare provider to consider alternative antihypertensive medications to manage the hypertension effectively without causing this bothersome side effect.