ATI RN
Chapter 14 Drugs for the Reproductive System Questions
Question 1 of 5
The following antidiabetic drug inhibits intestinal brush border α-glucosidase enzymes:
Correct Answer: A
Rationale: The correct answer is A: Acarbose. Acarbose inhibits intestinal brush border α-glucosidase enzymes, leading to delayed carbohydrate digestion and absorption. This mechanism helps in controlling postprandial blood glucose levels. Pioglitazone (B) improves insulin sensitivity, Metformin (C) reduces hepatic glucose production, and Guargum (D) is a dietary fiber with no direct impact on α-glucosidase enzymes.
Question 2 of 5
The following glucocorticoid has significant mineralocorticoid activity also:
Correct Answer: A
Rationale: Rationale: 1. Hydrocortisone is a natural glucocorticoid with significant mineralocorticoid activity. 2. It binds to both glucocorticoid and mineralocorticoid receptors. 3. This dual activity can lead to sodium retention and potassium excretion. 4. Triamcinolone, Dexamethasone, and Betamethasone are synthetic glucocorticoids with minimal mineralocorticoid effects. Summary: - Triamcinolone, Dexamethasone, and Betamethasone have negligible mineralocorticoid activity. - Hydrocortisone stands out due to its substantial mineralocorticoid effects alongside its glucocorticoid actions.
Question 3 of 5
Corticosteroid therapy is practically mandatory in the following condition:
Correct Answer: B
Rationale: Corticosteroid therapy is practically mandatory in renal transplant recipients to prevent organ rejection by suppressing the immune response. In renal transplant, the body identifies the new kidney as foreign and attacks it. Corticosteroids help modulate the immune system to prevent rejection. In septic shock, prompt antibiotics and supportive care are essential. In rheumatoid arthritis, disease-modifying antirheumatic drugs are preferred. In ulcerative colitis, corticosteroids may be used but are not mandatory.
Question 4 of 5
After chronic systemic therapy, withdrawal of corticosteroids should be gradual because:
Correct Answer: B
Rationale: The correct answer is B: Abrupt withdrawal may reactivate the underlying disease. When corticosteroids are used chronically, the body's natural production of cortisol is suppressed. Abruptly stopping corticosteroid therapy can lead to adrenal insufficiency and potentially reactivate the underlying disease due to the sudden drop in cortisol levels. Option A is incorrect because corticosteroids do not produce psychological dependence. Option C is incorrect as rebound hypertension is not a typical consequence of corticosteroid withdrawal. Option D is incorrect as only option B is directly related to the physiological consequences of abrupt corticosteroid withdrawal.
Question 5 of 5
For the treatment of hypogonadism and impotence, testosterone/dihydrotestosterone can be administered by the following route/routes:
Correct Answer: D
Rationale: The correct answer is D because testosterone and dihydrotestosterone are typically administered through intramuscular or transdermal routes. Intramuscular injection ensures direct delivery into the bloodstream, while transdermal patches allow for gradual absorption through the skin. Oral administration is not preferred due to liver metabolism. Therefore, options A and C alone are not sufficient. The combination of both intramuscular (B) and transdermal (C) routes provides effective and reliable delivery for treating hypogonadism and impotence.