The following anthelmintic has been found to be safe during pregnancy

Correct Answer: B

Rationale: In this NCLEX question on chemotherapy drugs, the correct answer is B) Piperazine, which has been found to be safe during pregnancy. Piperazine is an anthelmintic drug commonly used to treat parasitic worm infections and is considered safe for use during pregnancy due to its low systemic absorption and minimal adverse effects on the fetus. Option A) Thialbendazole is contraindicated during pregnancy as it can cause fetal harm and birth defects. Option C) Albendazole is also contraindicated in pregnancy due to its teratogenic effects. Option D) Pyrantel pamoate is not recommended during pregnancy as its safety profile is not well established and may pose risks to the developing fetus. Educational Context: Understanding the safety profiles of chemotherapy drugs during pregnancy is crucial for healthcare professionals, especially for nurses preparing for the NCLEX exam. Knowledge of which drugs are safe for use in pregnant individuals helps to ensure appropriate and effective treatment while minimizing risks to the fetus. It is essential to be aware of the specific contraindications and potential adverse effects of each drug to make informed clinical decisions and provide optimal care for pregnant patients.

Correct Answer: C

Rationale: The correct answer is C) Miconazole. Miconazole is an antifungal medication commonly used to treat candidiasis, a fungal infection caused by Candida species. Miconazole works by inhibiting the growth of the fungus and is effective in treating various types of candidiasis, including vaginal yeast infections, oral thrush, and skin infections. Option A) Griseofulvin is an antifungal medication used primarily to treat fungal infections of the skin, hair, and nails caused by dermatophytes, not candidiasis. Option B) Nitrofungin is not a commonly used antifungal medication for candidiasis treatment. It is more commonly associated with antibacterial properties. Option D) Streptomycin is an antibiotic that is not effective against fungal infections like candidiasis. Streptomycin is typically used to treat bacterial infections, particularly tuberculosis and other bacterial diseases. In an educational context, understanding the appropriate use of different classes of medications is crucial for healthcare providers, especially when dealing with specific conditions like candidiasis. Knowing the mechanisms of action and appropriate indications for drugs like Miconazole can help ensure optimal patient outcomes and prevent the misuse of medications. This question reinforces the importance of medication knowledge and the ability to differentiate between drug classes for effective treatment interventions.

Correct Answer: C

Rationale: The correct answer is C) Reduction of ergosterol synthesis. Azoles are a class of antifungal drugs that work by inhibiting the enzyme lanosterol 14-alpha-demethylase, which is crucial for the synthesis of ergosterol in fungal cell membranes. Ergosterol is essential for maintaining the integrity and function of the fungal cell membrane. By reducing ergosterol production, azoles disrupt the structure of the fungal cell membrane, leading to cell death. Option A) Inhibition of cell wall synthesis is incorrect because azoles do not target the synthesis of the fungal cell wall, but rather the cell membrane through ergosterol disruption. Option B) Inhibition of fungal protein synthesis is incorrect because azoles do not directly interfere with protein synthesis in fungi. Option D) Inhibition of DNA synthesis is incorrect because azoles do not target DNA synthesis processes in fungi. Educationally, understanding the mechanism of action of azoles is vital for nursing students preparing for the NCLEX exam. Knowing how these drugs work allows nurses to provide safe and effective care to patients receiving antifungal therapy. This knowledge helps in proper administration, monitoring for adverse effects, and understanding the rationale behind treatment outcomes.

Correct Answer: D

Rationale: In this NCLEX question testing knowledge of chemotherapy drugs with a focus on fungicidal effects, the correct answer is D) Miconazole. A fungicidal effect refers to the ability of a drug to kill fungi. Miconazole, unlike the other options, is a fungistatic drug, meaning it inhibits the growth of fungi without directly killing them. Option A, Terbinafine, is a fungicidal drug commonly used to treat fungal skin infections. Option B, Amphotericin B, is a fungicidal drug used for severe systemic fungal infections. Option C, Ketoconazole, also has fungicidal properties and is used to treat a variety of fungal infections. Understanding the fungicidal properties of chemotherapy drugs is crucial in clinical practice, especially in the treatment of fungal infections. Nurses and healthcare professionals need to be able to differentiate between fungicidal and fungistatic drugs to provide effective treatment and prevent the development of drug resistance in fungal infections. This knowledge is vital for patient care and medication management in various healthcare settings.

Correct Answer: B

Rationale: Rationale: The correct answer is B) Peripheral neuritis. Isoniazid is a commonly used medication for the treatment of tuberculosis. One of its well-known side effects is peripheral neuritis, which is inflammation of the peripheral nerves leading to symptoms such as tingling, numbness, and pain in the extremities. Option A) Inhibition of protein synthesis is incorrect because isoniazid does not interfere with protein synthesis. Option C) Inhibition of RNA synthesis is incorrect as isoniazid does not impact RNA synthesis. Option D) Inhibition of ADP synthesis is also incorrect as isoniazid is not known to inhibit ADP synthesis. Educational Context: Understanding the side effects of chemotherapy drugs like isoniazid is crucial for healthcare professionals, especially for nurses and pharmacists who are responsible for administering medications and monitoring patients for adverse effects. Peripheral neuritis can significantly impact a patient's quality of life and may require dose adjustments or additional interventions. By knowing the side effects of each chemotherapy drug, healthcare providers can ensure safe and effective care for their patients undergoing treatment.