ATI RN
Pediatric Genetic Disorders Questions
Question 1 of 5
The first step in FAP colon cancer usually involves mutation of the gene:
Correct Answer: A
Rationale: APC mutation is the initial event in FAP, leading to adenoma formation.
Question 2 of 5
Sporadic cancers result from:
Correct Answer: A
Rationale: Sporadic cancers arise from somatic mutations in an individual’s lifetime, not inherited.
Question 3 of 5
Which statement concerning a pair of alleles for a gene controlling a single characteristic in humans is true?
Correct Answer: C
Rationale: Diploid organisms inherit one allele from each parent for each gene.
Question 4 of 5
Complete the following sentence. The Philadelphia chromosome (associated with chronic myelogenous leukemia):
Correct Answer: B
Rationale: The Philadelphia chromosome is a t(9;22) reciprocal translocation creating BCR-ABL.
Question 5 of 5
Marked microsatellite instability is a feature of:
Correct Answer: B
Rationale: HNPCC (Lynch syndrome) features microsatellite instability due to DNA mismatch repair defects.