The First-line tuberculosis drugs include:

Correct Answer: A

Rationale: The correct answer is A: Isoniazid and rifampicin. These drugs are considered first-line treatment for tuberculosis due to their high efficacy and low toxicity. Isoniazid targets the cell wall of the tuberculosis bacteria, while rifampicin inhibits RNA synthesis. They are recommended by WHO as the first choice for treating tuberculosis. Choice B (Penicillin and erythromycin) is incorrect because these antibiotics are not effective against tuberculosis bacteria. Choice C (Trimethoprim and third generation cephalosporins) is incorrect because they are not considered first-line drugs for tuberculosis treatment. Choice D (All the listed above can be used depending on their resistance profile) is incorrect because only isoniazid and rifampicin are universally recognized as first-line drugs for tuberculosis regardless of resistance profile.

Correct Answer: B

Rationale: The correct answer is B: Cell-wall regrowth. This is not a bacterial antibiotic resistance mechanism because antibiotics target specific components in bacteria, such as cell wall synthesis, making regrowth impossible in the presence of antibiotics. Reduced permeability (A) decreases antibiotic entry, Over-expression of target (C) reduces antibiotic effectiveness, and Efflux pump (D) actively removes antibiotics from the cell, all contributing to antibiotic resistance. In summary, cell-wall regrowth is not a mechanism of antibiotic resistance, unlike the other choices that actively promote bacterial survival against antibiotics.

Correct Answer: C

Rationale: The correct answer is C: Obligate anaerobes cannot tolerate oxygen. They lack the enzymes needed to detoxify reactive oxygen species generated in the presence of oxygen. This makes them unable to survive in oxygen-rich environments. Choice A is incorrect because obligate anaerobes do not require oxygen to survive. Choice B is incorrect because obligate anaerobes specifically require the absence of oxygen. Choice D is incorrect because obligate anaerobes cannot even tolerate low levels of oxygen.

Correct Answer: A

Rationale: Rationale for Correct Answer (A: Fluconazole): Fluconazole is an antifungal medication used to treat yeast infections caused by Candida albicans. It targets the fungal cell membrane, disrupting its structure and function. This makes it an effective treatment for oral thrush, which is caused by Candida overgrowth in the oral mucosa. The continuous use of antibiotics can disrupt the normal balance of microorganisms in the body, leading to fungal overgrowth. Fluconazole specifically targets the yeast fungi without affecting bacteria, making it the appropriate choice for this complication. Summary of Incorrect Choices: B: Biseptol - Biseptol is an antibiotic that targets bacteria, not fungi like Candida albicans. C: Tetracycline - Tetracycline is also an antibiotic that targets bacteria, not fungi. D: Furazolidone - Furazolidone is an antibiotic primarily used for treating bacterial infections, not fungal infections like oral thrush caused by Candida

Correct Answer: B

Rationale: The correct answer is B: resisting phagocytosis. Bacterial capsules are composed of polysaccharides that help bacteria evade phagocytosis by immune cells. This physical barrier prevents immune cells from engulfing and destroying the bacteria. Facilitating motility (A), synthesizing DNA (C), and producing energy (D) are not primary functions of bacterial capsules. Motility is usually facilitated by flagella, DNA synthesis occurs in the bacterial chromosome, and energy production is typically carried out by metabolic processes within the bacterial cell.