The first clinical manifestation of acquired hypothyroidism is

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Pediatric Endocrine Exam Questions Questions

Question 1 of 5

The first clinical manifestation of acquired hypothyroidism is

Correct Answer: C

Rationale: Growth deceleration (C) is often the earliest sign of acquired hypothyroidism in children.

Question 2 of 5

Episodic symptomatic hypocalcemia occurs in the Kenny-Caffey syndrome, the latter is characterized by the following EXCEPT

Correct Answer: D

Rationale: Kenny-Caffey syndrome features delayed bone age, not advanced (D).

Question 3 of 5

Glucocorticoids readily penetrate the blood-brain barrier and have direct effects on brain metabolism. They have the following actions EXCEPT

Correct Answer: D

Rationale: Glucocorticoids impair concentration (not improve, E) and cause insomnia (B), irritability (C), and memory issues (D).

Question 4 of 5

High-dose glucocorticoids (the equivalent of >10 times physiologic cortisol secretion) can be administered without requiring a subsequent tapering for

Correct Answer: B

Rationale: Up to 7 days (B) of high-dose glucocorticoids can be stopped without tapering, as HPA axis suppression is minimal.

Question 5 of 5

All the following tests are of diagnostic utility in the diagnosis of Cushing syndrome EXCEPT

Correct Answer: C

Rationale: Glucose tolerance test (C) assesses diabetes, not Cushing syndrome directly; others (A, B, D, E) are diagnostic.

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