ATI RN
Pediatric Genetics Questions
Question 1 of 5
The figure depicts two possible graphs of an assumed population genetic diversity. In comparison to each other:
Correct Answer: D
Rationale: Crossing over in meiosis increases diversity (D is correct). Rationale: Crossing over (prophase I) shuffles alleles, favoring higher diversity (graph B likely shows more variation). A and B are false (crossing over is meiotic), C reverses logic.
Question 2 of 5
A child person with clinical features that include: cardiovascular, brain with neurological, renal, gastrointestinal, respiratory, and skeletal malformations, craniofacial abnormalities such as prominent occiput, hand and feet anomalies including clenched hand. This patient is most probably affected with:
Correct Answer: A
Rationale: Trisomy 18 (Edwards syndrome, A) fits. Rationale: Clenched hands, multiple organ defects, and craniofacial issues (e.g., prominent occiput) are hallmark Edwards features. Down (B, D) lacks these specifics; Turner (C) differs (e.g., lymphedema).
Question 3 of 5
The chromatin in interphase and in M phase
Correct Answer: C
Rationale: Chromatin is decondensed in interphase (for gene expression) and condensed in M phase (mitosis, for segregation). 'C' (Decondensed, Condensed) is correct. Rationale: Interphase chromatin is diffuse to allow transcription, while M phase (prophase to metaphase) condenses chromosomes into visible, compact structures for division.
Question 4 of 5
Law of segregation related to and law of independent assortment related to
Correct Answer: B
Rationale: Segregation involves homologous chromosomes separating; independent assortment involves different chromosomes assorting independently. 'B' is correct. Rationale: Mendel’s laws: segregation (alleles on homologs split in meiosis I), assortment (non-homologous chromosomes align randomly).
Question 5 of 5
The location of alpha satellite:
Correct Answer: B
Rationale: Alpha satellite DNA is at the centromere (B). Rationale: These repetitive sequences define the centromere, aiding kinetochore attachment, distinct from telomeres or p-arms of acrocentrics.