The experiment shown in Figure Q6.19 uses two strains of mice that differ in their MHC genes. Strain A is H-2^a and Strain B is H-2^b. Mice of each strain are infected with the virus LCMV, and T cells are isolated at day 8 post-infection. These T cells are mixed with target cells that express either H-2^a or H-2^b; in each case, the target cells are either uninfected or infected with LCMV. The explanation for the results of this experiment is:

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Lymphatic System Multiple Choice Questions and Answers Questions

Question 1 of 5

The experiment shown in Figure Q6.19 uses two strains of mice that differ in their MHC genes. Strain A is H-2^a and Strain B is H-2^b. Mice of each strain are infected with the virus LCMV, and T cells are isolated at day 8 post-infection. These T cells are mixed with target cells that express either H-2^a or H-2^b; in each case, the target cells are either uninfected or infected with LCMV. The explanation for the results of this experiment is:

Correct Answer: D

Rationale: T cells are MHC-restricted; strain A T cells recognize H-2^a ; both strains respond (A, B), H-2^b cells are infected .

Question 2 of 5

When a B cell first interacts with its particular antigen, the B cell

Correct Answer: C

Rationale: B cells, upon antigen binding, differentiate into plasma cells that produce antibodies, not dying, engulfing, or altering antigens.

Question 3 of 5

Where is the antigen-binding site of this antibody?

Correct Answer: A

Rationale: The antigen-binding site is at site A (assumed figure), located at the variable regions of the antibody's arms.

Question 4 of 5

Complete this sentence. Mature dendritic cells.

Correct Answer: C

Rationale: Mature DCs form dendrites to present antigens to T cells, unlike immature DCs (uptake) or granulocytes (not primary targets).

Question 5 of 5

In addition to CD40 ligation, which of the statements below identify a cytokine that induce a correct antibody isotype?

Correct Answer: B

Rationale: IL-4/IL-13 drive IgE switching (allergy), while IFNγ (IgG) and TGFβ (IgA) induce other isotypes.

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