The earliest clinical feature of ataxia-telangiectasia is

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Pediatric Immunizations NCLEX Questions Questions

Question 1 of 5

The earliest clinical feature of ataxia-telangiectasia is

Correct Answer: A

Rationale: Ataxia, due to cerebellar degeneration, is typically the earliest sign of ataxia-telangiectasia, appearing in early childhood.

Question 2 of 5

A 3-year-old boy presented with recurrent subcutaneous abscesses, lymphadenitis, osteomyelitis, and family history of recurrent infections. The hallmark of this condition is

Correct Answer: D

Rationale: Chronic granulomatous disease (CGD) is marked by granuloma formation due to defective phagocyte killing, leading to recurrent abscesses.

Question 3 of 5

Phagocytic white cells (leukocytes, e.g. macrophages) congregate within when foreign organisms get through a cut in the skin.

Correct Answer: D

Rationale: Phagocytes like macrophages take hours to congregate at an infection site via chemotaxis, as this involves signaling, migration, and accumulation after a breach in the skin.

Question 4 of 5

Which of the following is NOT true when comparing innate to adaptive immunity?

Correct Answer: C

Rationale: Innate immunity lacks immunologic memory, while adaptive immunity has it, making option c the incorrect statement.

Question 5 of 5

How many doses of the Hepatitis B vaccine (5 μg HBsAg in 0.5 mL intramuscular) are required to reach a protective level of antibody?

Correct Answer: C

Rationale: The standard Hepatitis B vaccine requires three doses to achieve protective antibody levels, typically at 0, 1, and 6 months.

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