The criteria for successful bone marrow transplantation in thalassemic patients include all the following EXCEPT

Correct Answer: C

Rationale: Successful BMT in thalassemia favors young age (A), no hepatomegaly (B), no iron overload (D), and HLA match (E). Bone deformities (C) don’t preclude success, though they indicate disease severity.

Correct Answer: B

Rationale: Hookworm (A), celiac (C), heart disease (D), and INH (E) cause iron loss or malabsorption. Prolonged hemolysis (B) leads to iron overload from transfusions, not deficiency.

Correct Answer: C

Rationale: Gamma irradiation (C) inactivates lymphocytes in blood products, preventing GVHD in immunocompromised recipients, unlike bacterial (A), viral (B), allergic (D), or TRALI (E) risks.

Correct Answer: D

Rationale: Factor XIII deficiency (E) causes severe bleeding, including intracranial hemorrhage, due to unstable clots, more than factor VII (A), VIII (B), IX (C), or XI (D) deficiencies.

Correct Answer: A

Rationale: Vitamin K-dependent factors are II (B), VII (C), IX (D), and protein S (E). Factor I (A, fibrinogen) is not vitamin K-dependent.