The correct hierarchical order for virus classification is

Correct Answer: C

Rationale: The correct hierarchical order for virus classification is order, family, subfamily, genus, species. This is because classification starts at a broader level (order) and narrows down to a more specific level (species). Order comes first to group viruses based on common characteristics, followed by family, which further categorizes them. Subfamily refines the classification, then genus groups similar viruses together, and species distinguishes different strains within a genus. Choice A is incorrect because it places genus before family, which is not the correct sequence. Choice B is incorrect as it starts with species, which is the most specific level. Choice D is incorrect because it places genus at the beginning, which is too specific for the hierarchical order.

Correct Answer: A

Rationale: The correct answer is A because fires from combustibles such as wood fall under Class A fires. Type A fire extinguishers are specifically designed to extinguish fires involving ordinary combustible materials like wood, paper, and cloth. Choice B, C, and D are incorrect because they do not correspond to the correct classification of the fire. Choice B refers to Class B fires involving flammable liquids, Choice C refers to Class C fires involving electrical equipment, and Choice D refers to Class D fires involving combustible metals. It is crucial to match the type of fire extinguisher with the type of fire to effectively combat the fire.

Correct Answer: B

Rationale: The correct answer is B: Sugar meat pepton broth, sugar meat pepton agar. These nutrient media are optimal for Corynebacterium diphtheriae cultivation due to their ability to support the growth of this bacterium. Sugar meat pepton broth provides a liquid medium with essential nutrients, while sugar meat pepton agar provides a solid surface for bacterial growth and isolation. Incorrect choices: A: Diphtheriae does not require specific conditions for cultivation. C: Salt egg yolk agar is not commonly used for Corynebacterium diphtheriae. D: Endomedium and Ploskirev medium are not standard media for diphtheria testing.

Correct Answer: A

Rationale: The correct answer is A: Isoniazid. When rifampicin is used alone, there is a risk of developing resistance. Isoniazid is commonly used in combination with rifampicin to prevent resistance by targeting different mechanisms in the bacteria. Isoniazid works by inhibiting mycolic acid synthesis, while rifampicin targets RNA polymerase. This combination therapy is known as the first-line treatment for tuberculosis. Choices B, C, and D are incorrect because they do not have the same mechanism of action as isoniazid and would not be effective in preventing rifampicin resistance.

Correct Answer: D

Rationale: The correct answer is D. Isoniazid inhibits pyridoxal phosphate synthesis, which is the active form of vitamin B6. Pyridoxal phosphate is essential for various enzymatic reactions, including neurotransmitter synthesis and myelin formation. Therefore, isoniazid-induced pyridoxal phosphate deficiency can lead to neurological symptoms like polyneuritis, paresthesia, memory disorders, and convulsions. A: Disruption of cell membrane synthesis - This is not the mechanism of isoniazid side-effects. B: Inhibition of protein synthesis - Isoniazid does not directly inhibit protein synthesis. C: Inhibition of RNA-synthesis - Isoniazid does not inhibit RNA synthesis; it affects vitamin B6 metabolism.