The commonest translocation in infantile acute lym

ATI RN

ATI RN Test Bank

The commonest translocation in infantile acute lymphoblastic leukemia is

A. t(12;21) B. t(9;22) C. t(4;11) D. t(1;19)

Correct Answer: C

Rationale: t(4;11) (MLL rearrangement) is the most frequent translocation in infantile ALL, linked to poor prognosis.

The LEAST likely presenting feature for a newly diagnosed 3-year-old girl with non-Hodgkin's lymphoma is

A. fever B. pallor C. abdominal distension D. jaundice

Correct Answer: D

Rationale: Jaundice is uncommon in non-Hodgkin lymphoma unless there is significant liver or biliary involvement.

During follow up of a surgically resected brain tumor, the examination of choice to distinguish recurrent tumor from radiation necrosis is

A. computed tomography B. magnetic resonance spectroscopy C. cerebrospinal fluid analysis D. positron emission topography

Correct Answer: B

Rationale: Magnetic resonance spectroscopy differentiates tumor recurrence from radiation necrosis by metabolic profiling.

The LEAST likely presentation of neuroblastoma is

A. weakness of both lower limbs B. Horner syndrome C. secretary diarrhea D. vomiting

Correct Answer: D

Rationale: Vomiting is less specific and less common as a primary presentation of neuroblastoma compared to the others.

A favorable prognostic factor in neuroblastoma is

A. lack of cell differentiation B. amplification of the MYCN oncogene C. lack of hyperdiploidy D. stage 4S

Correct Answer: D

Rationale: Stage 4S neuroblastoma has a favorable prognosis with potential for spontaneous regression.

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