The commonest cause of jaundice in thalassemia is:

Correct Answer: D

Rationale: The correct answer is D: haemolysis. In thalassemia, there is an abnormality in hemoglobin production leading to the destruction of red blood cells, causing hemolysis. This results in the release of bilirubin, leading to jaundice. Iron deposition in the liver (choice B) is seen in conditions like hemochromatosis, not thalassemia. Viral hepatitis B and C (choices A and C) can cause jaundice, but they are not the commonest cause in thalassemia patients, as hemolysis is the primary mechanism in this population.

Correct Answer: D

Rationale: Rationale: Splenectomy is curative in hereditary spherocytosis because it removes the site of red blood cell destruction. The spleen is responsible for filtering out abnormal or damaged red blood cells in this condition. Removing the spleen stops the destruction of spherocytes, leading to an improvement in anemia. Summary of other choices: A: G6PD def. - Splenectomy does not address the underlying enzyme deficiency causing hemolysis. B: ITP - Splenectomy is used in refractory cases of ITP, but not considered curative. C: Thalassemia - Splenectomy can be used to manage complications in thalassemia but does not cure the underlying genetic defect.

Correct Answer: C

Rationale: Thrombocytopenia is absent in Henoch Schonlein purpura because it primarily involves vasculitis, not platelet destruction or consumption. In DIC (A), there is widespread activation of coagulation leading to thrombocytopenia. Wiskott Aldrich syndrome (B) is characterized by low platelet counts due to defective platelet function. Myelosclerosis (D) is a bone marrow disorder causing decreased platelet production, leading to thrombocytopenia.

Correct Answer: B

Rationale: Step-by-step rationale: 1. Sideroblastic anemia results in defective heme synthesis, leading to iron accumulation in the mitochondria. 2. This excess iron saturation decreases the Iron Binding Capacity (IBC) in the serum. 3. Therefore, in sideroblastic anemia, increasing serum iron is associated with a decrease in IBC. Summary of other choices: A: Hookworm infestation causes iron deficiency anemia with increased IBC. C: Alcoholic liver disease can lead to iron overload, not a decrease in IBC. D: Thalassemia major is associated with increased IBC due to ineffective erythropoiesis.

Correct Answer: D

Rationale: The correct answer is D because individuals with G6PD deficiency can have normal enzyme levels shortly after a hemolytic episode due to the body replenishing the enzyme. Choice A, iron deficiency anemia, is unrelated to G6PD deficiency. Choice B, hypoplastic anemia, does not affect enzyme levels. Choice C, hairy cell leukemia, is not typically associated with false-normal G6PD levels. Therefore, the correct answer is D as it reflects the transient nature of G6PD levels post-hemolysis.