ATI RN
ATI Hematologic System Test Questions
Question 1 of 5
The commonest cause of jaundice in thalassemia is:
Correct Answer: D
Rationale: The correct answer is D: haemolysis. In thalassemia, there is an increased breakdown of red blood cells leading to excessive production of bilirubin causing jaundice. Viral hepatitis B and C do not directly cause jaundice in thalassemia. Iron deposition in the liver is seen in iron overload conditions like hemochromatosis, not thalassemia. Haemolysis in thalassemia is the primary reason for jaundice.
Question 2 of 5
Splenectomy is curative in:
Correct Answer: D
Rationale: The correct answer is D: hereditary spherocytosis. Splenectomy is curative in hereditary spherocytosis because the spleen is responsible for the destruction of the abnormal spherocytes in this condition. Removing the spleen eliminates the primary site of red blood cell destruction, leading to an improvement in anemia and other symptoms. Incorrect choices: A: Splenectomy is contraindicated in G6PD deficiency as it can worsen hemolysis by increasing the workload on other organs. B: Splenectomy can be beneficial in ITP to increase platelet counts but is not curative as the underlying autoimmune process persists. C: Splenectomy is not curative in thalassemia as it does not address the underlying genetic defect causing abnormal hemoglobin synthesis.
Question 3 of 5
Thrombocytopenia is absent in:
Correct Answer: C
Rationale: Thrombocytopenia is absent in Henoch Schonlein purpura because it is primarily a vasculitis affecting small blood vessels, not directly causing platelet destruction. Thrombocytopenia is present in DIC due to widespread coagulation activation. Wiskott Aldrich syndrome and myelosclerosis both involve platelet dysfunction or decreased production, leading to thrombocytopenia.
Question 4 of 5
Increase serum iron:-decrease IBC a feature of:
Correct Answer: B
Rationale: The correct answer is B: sideroblastic anemia. In sideroblastic anemia, there is impaired heme synthesis leading to the accumulation of iron in the mitochondria of red blood cell precursors. This results in increased serum iron levels due to the release of iron from the mitochondria. Decreased Iron Binding Capacity (IBC) occurs as a compensatory mechanism due to the increased serum iron levels. Choice A, hookworm infestation, would typically result in iron deficiency anemia with decreased serum iron levels and normal to increased IBC. Choice C, alcoholic liver disease, is associated with decreased serum iron levels and normal to increased IBC due to impaired iron metabolism. Choice D, thalassemia major, presents with normal to decreased serum iron levels and normal to increased IBC due to ineffective erythropoiesis.
Question 5 of 5
C6PD reflect false normal report in:
Correct Answer: D
Rationale: The correct answer is D, shortly after hemolysis, because G6PD deficiency leads to a false-normal result due to the presence of reticulocytes in the blood following hemolysis. This is because reticulocytes have normal enzyme activity, masking the underlying deficiency. Iron deficiency anemia (A), hypoplastic anemia (B), and hairy cell leukemia (C) do not involve the same mechanism of false-normal reports in C6PD deficiency as seen in hemolysis.