The client says to the nurse, 'My wife and I take the same drug, but we have different side effects. Are we doing something wrong?' What is the best response by the nurse?

Correct Answer: A

Rationale: Sex differences affect drug metabolism (e.g., liver enzymes, body fat), leading to varied side effects, a normal pharmacodynamic variation, reassuring the client they're not at fault. Checking the drug delays a clear answer. Generic vs. brand typically doesn't alter side effects-bioequivalence is required. Uncertainty muddies education. Sex-based differences offer a concise, accurate explanation, normalizing their experience and enhancing understanding.

Correct Answer: A

Rationale: The correct definition for absorption of a drug is the movement of a drug from the site of administration (e.g., mouth, skin, injection site) into the bloodstream and then to various tissues of the body. This process is a critical step in the pharmacokinetics of a drug, as it determines the rate and extent to which the drug reaches its target site of action. Absorption can be affected by various factors such as the route of administration, drug formulation, and physiological factors of the individual.

Correct Answer: C

Rationale: Transdermal nitroglycerin patches are most appropriately used to prevent the occurrence of angina. Nitroglycerin is a vasodilator that works by relaxing and widening blood vessels, which helps to increase blood flow and oxygen to the heart muscle. By using nitroglycerin patches regularly, the patient can help prevent episodes of angina, which is chest pain or discomfort that occurs when the heart muscle does not receive enough oxygen-rich blood. Nitroglycerin patches are not used to prevent low blood pressure, relieve shortness of breath, or control heart rate during exercise.

Correct Answer: B

Rationale: Colchicine should be used with caution in patients with aplastic anemia or other blood dyscrasias, as it can exacerbate bone marrow suppression. While colchicine is used to treat conditions like Behcet disease and familial Mediterranean fever, it is not contraindicated in these conditions. Amyloidosis is not a primary concern with colchicine use. Monitoring blood counts is essential in patients with pre-existing hematologic conditions.

Correct Answer: A

Rationale: Gentamicin is associated with nephrotoxicity, particularly when administered in high doses or for prolonged periods.