The client is experiencing a drug-drug interaction with streptokinase and another drug. Which other drug can cause a drug-drug interaction with streptokinase?

Correct Answer: C

Rationale: Rationale: 1. Heparin interacts with streptokinase by increasing the risk of bleeding due to their combined anticoagulant effects. 2. Streptokinase can enhance the anticoagulant effects of heparin, leading to potential bleeding complications. 3. Cimetidine, theophylline, and digoxin do not directly interact with streptokinase in the same manner as heparin. Summary: - A: Cimetidine is not known to interact with streptokinase in a significant way. - B: Theophylline does not have a direct drug-drug interaction with streptokinase. - D: Digoxin does not interact with streptokinase to cause a drug-drug interaction.

Correct Answer: A

Rationale: The correct answer is A: Nausea and vomiting. Anti-arrhythmic drugs commonly cause gastrointestinal side effects like nausea and vomiting due to their impact on the digestive system. B: Hypotension is not a common side effect of anti-arrhythmic drugs. These medications are more likely to cause arrhythmias than low blood pressure. C: Pro-arrhythmic effect is a potential concern with anti-arrhythmic drugs, but not a common side effect. It refers to the drug actually causing or worsening arrhythmias. D: Constipation is not a typical side effect of anti-arrhythmic drugs. Gastrointestinal side effects like diarrhea are more common. In summary, the correct answer is A because nausea and vomiting are commonly associated with anti-arrhythmic drugs, while hypotension, pro-arrhythmic effects, and constipation are less likely side effects.

Correct Answer: A

Rationale: The correct answer is A: Decreases preload. Organic nitrates work by dilating veins, which results in decreased venous return to the heart, leading to reduced preload. This reduces the workload on the heart and oxygen demand, helping to relieve angina symptoms. Incorrect choices: B: Increases afterload - Organic nitrates do not increase afterload. They primarily affect preload by dilating veins. C: Constricts arterioles - Organic nitrates actually dilate arterioles, leading to decreased systemic vascular resistance. D: Increases preload - Organic nitrates decrease preload by dilating veins, resulting in decreased venous return to the heart.

Correct Answer: C

Rationale: The correct answer is C: Thrombocytopenia. Heparin can cause a decrease in platelet count, leading to thrombocytopenia. This can increase the risk of bleeding. Pulmonary embolism (A) and deep vein thrombosis (B) are conditions that heparin is used to prevent, not adverse reactions. Neutropenia (D) is a decrease in neutrophils, which is not a common adverse reaction of heparin. Therefore, the nurse should monitor for thrombocytopenia as an adverse reaction when the client is taking IV heparin.

Correct Answer: B

Rationale: Step-by-step rationale for choice B: 1. Pradaxa is a direct thrombin inhibitor. 2. Thrombin is a key enzyme in the blood clotting process. 3. By directly inhibiting thrombin, Pradaxa prevents the formation of blood clots. 4. This mechanism differs from antiplatelet drugs (A), fibrinolytic medications (C), and clotting factor production interference (D). Summary: - Choice A is incorrect as Pradaxa does not affect platelets directly. - Choice C is incorrect as Pradaxa does not promote the breakdown of clots like fibrinolytics. - Choice D is incorrect as Pradaxa does not interfere with the production of clotting factors.