The childhood kidney cancer Wilms tumor is caused

ATI RN

ATI RN Test Bank

The childhood kidney cancer Wilms’ tumor is caused by:

A. Activation of an oncogene B. Translocation of an oncogene C. Loss of a tumor suppressor gene D. A transposon

Correct Answer: C

Rationale: Wilms’ tumor is associated with loss of the WT1 tumor suppressor gene on chromosome 11p13.

DNA microarrays and human genome data are being used to diagnose and manage cancer:

A. TRUE B. FALSE C. D.

Correct Answer: A

Rationale: True. Microarrays and genomic data help identify cancer mutations and guide treatment.

cells are commonly used today in research laboratories. They are from a cervical cancer patient who died in 1951:

A. HeLa B. PSA C. AML D. CML

Correct Answer: A

Rationale: HeLa cells, from Henrietta Lacks’ cervical cancer, are widely used in research.

The characteristic indicated by the blackened figures is probably:

A. Dominant B. Recessive C. Non-dominant D. Sex-linked recessive

Correct Answer: A

Rationale: Without the pedigree, dominant is assumed if blackened figures appear in every generation; recessive if skipping generations.

Consanguinity shows a strong association with which pattern of inheritance?

A. Autosomal dominant B. Autosomal recessive C. X-linked dominant D. X-linked recessive

Correct Answer: B

Rationale: Consanguinity increases the risk of autosomal recessive disorders due to shared rare alleles.

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