ATI RN
Pediatric Genetic Disorders Questions
Question 1 of 5
The BRAC1 gene is involved in regulating:
Correct Answer: C
Rationale: BRCA1 (likely meant here) is a tumor suppressor involved in DNA repair, particularly double-strand breaks.
Question 2 of 5
Which statement concerning a pair of alleles for a gene controlling a single characteristic in humans is true?
Correct Answer: C
Rationale: Diploid organisms inherit one allele from each parent for each gene.
Question 3 of 5
Complete the following sentence. The Philadelphia chromosome (associated with chronic myelogenous leukemia):
Correct Answer: B
Rationale: The Philadelphia chromosome is a t(9;22) reciprocal translocation creating BCR-ABL.
Question 4 of 5
Marked microsatellite instability is a feature of:
Correct Answer: B
Rationale: HNPCC (Lynch syndrome) features microsatellite instability due to DNA mismatch repair defects.
Question 5 of 5
The most common chromosome abnormality in first trimester spontaneous miscarriages is:
Correct Answer: A
Rationale: Trisomy (e.g., trisomy 16) is the most common chromosomal cause of early miscarriage.